Alterations of cell-mediated immune response in children with febrile seizures

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorMontelli, Terezinha C.B.
dc.creatorSoares, Angela M.V.C.
dc.creatorParise-Fortes, Maria R.
dc.creatorRezkallah-Iwasso, Maria T.
dc.creatorPadula, Niura M.R.
dc.creatorPeraçoli, Maria Terezinha S.
dc.date2014-05-27T11:18:14Z
dc.date2016-10-25T18:14:29Z
dc.date2014-05-27T11:18:14Z
dc.date2016-10-25T18:14:29Z
dc.date1997-06-01
dc.date.accessioned2017-04-06T00:49:41Z
dc.date.available2017-04-06T00:49:41Z
dc.identifierArquivos de Neuro-Psiquiatria, v. 55, n. 2, p. 193-198, 1997.
dc.identifier0004-282X
dc.identifierhttp://hdl.handle.net/11449/65119
dc.identifierhttp://acervodigital.unesp.br/handle/11449/65119
dc.identifier10.1590/S0004-282X1997000200005
dc.identifierS0004-282X1997000200005
dc.identifierWOS:A1997XB39000005
dc.identifier2-s2.0-0031151979.pdf
dc.identifier2-s2.0-0031151979
dc.identifierhttp://dx.doi.org/10.1590/S0004-282X1997000200005
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/886871
dc.descriptionThe aim of the present investigation was to study the distribution of T-cell subsets in peripheral blood defined by monoclonal antibodies and by the lymphocyte proliferative response to phytohemagglutinin (PHA) in 30 children with febrile seizures and in 14 age-matched control subjects. Frequent respiratory, urinary and dermatologic infections were observed in 22 patients. The immunologic parameters showed that 64% of the patients presented an increased number of CD8+ cells and a low helper/suppressor ratio was observed in 60% of the patients. In addition, the proliferative response of lymphocytes to PHA was impaired in the patients It was observed the presence of inhibitory activity on lymphocyte function in the plasma of 33% of children with febrile seizures. These results suggest that patients with febrile seizures have an impairment of cellular immunity that may be connected with this epileptic syndrome and explain the infections observed.
dc.languageeng
dc.relationArquivos de Neuro-Psiquiatria
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectFebrile seizures
dc.subjectInfections
dc.subjectLymphocyte proliferative response
dc.subjectT cell subsets
dc.subjectdiagnostic agent
dc.subjectimmunoglobulin G
dc.subjectphytohemagglutinin
dc.subjectphytohemagglutinin P
dc.subjectphytohemagglutinin-P
dc.subjectblood
dc.subjectCD4 CD8 ratio
dc.subjectfebrile convulsion
dc.subjectfemale
dc.subjectfollow up
dc.subjecthuman
dc.subjectimmunology
dc.subjectinfant
dc.subjectmale
dc.subjectpreschool child
dc.subjectprospective study
dc.subjectT lymphocyte subpopulation
dc.subjectCD4-CD8 Ratio
dc.subjectChild, Preschool
dc.subjectFemale
dc.subjectFollow-Up Studies
dc.subjectHumans
dc.subjectImmunoglobulin G
dc.subjectInfant
dc.subjectMale
dc.subjectPhytohemagglutinins
dc.subjectProspective Studies
dc.subjectSeizures, Febrile
dc.subjectT-Lymphocyte Subsets
dc.titleAlterations of cell-mediated immune response in children with febrile seizures
dc.typeOtro


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