Otro
Functional evidence that the central renin-angiotensin system plays a role in the pressor response induced by central injection of carbachol
Registration in:
Brazilian Journal of Medical and Biological Research, v. 30, n. 4, p. 493-496, 1997.
0100-879X
10.1590/S0100-879X1997000400010
S0100-879X1997000400010
WOS:A1997WT02000010
2-s2.0-0030958097.pdf
2-s2.0-0030958097
Author
Saad, William A.
Luiz, A. C.
Camargo, L. A A
Silveira, J. E N
Fóglia, S.
Menani, José Vanderlei
Abstract
We investigated the effects of losartan, an AT 1-receptor blocker, and ramipril, a converting enzyme inhibitor, on the pressor response induced by angiotensin II (ANG II) and carbachol (a cholinergic receptor agonist). Male Holtzman rats (250-300 g) with a stainless steel cannula implanted into the lateral ventricle (LV) were used. The injection of losartan (50 nmol/l μl) into the LV blocked the pressor response induced by ANG II (12 ng/l μl) and carbachol (2 nmol/l μl). After injection of ANG II and carbachol into the LV, mean arterial pressure (MAP) increased to 31 ± 1 and 28 ± 2 mmHg, respectively. Previous injection of losartan abolished the increase in MAP induced by ANG II and carbachol into the LV (2 ± 1 and 5 ± 2 mmHg, respectively). The injection of ramipril (12 ng/l μl) prior to carbachol blocked the pressor effect of carbachol to 7 ± 3 mmHg. These results suggest an interaction between central cholinergic pathways and the angiotensinergic system in the regulation of arterial blood pressure.
Subjects
Related items
Showing items related by title, author, creator and subject.
-
Aerobic Exercise Training-Induced Left Ventricular Hypertrophy Involves Regulatory MicroRNAs, Decreased Angiotensin-Converting Enzyme-Angiotensin II, and Synergistic Regulation of Angiotensin-Converting Enzyme 2-Angiotensin (1-7)
FERNANDES, Tiago; HASHIMOTO, Nara Y.; MAGALHAES, Flavio C.; FERNANDES, Fernanda B.; CASARINI, Dulce E.; CARMONA, Adriana K.; KRIEGER, Jose E.; PHILLIPS, M. Ian; OLIVEIRA, Edilamar M. (LIPPINCOTT WILLIAMS & WILKINS, 2011)Aerobic exercise training leads to a physiological, nonpathological left ventricular hypertrophy; however, the underlying biochemical and molecular mechanisms of physiological left ventricular hypertrophy are unknown. The ... -
New specific angiotensin antagonists - [8-valine]-angiotensins i, [8-isoleucine]-angiotensins I, and chlorambucil-des-1-aspartic,8-valine-angiotensins I
Paiva, Antonio Cechelli de Mattos [UNIFESP]; NOUAILHE.VL; Miyamoto, M. E.; Bergsten-Mendes, Gun [UNIFESP]; Paiva, Therezinha Bandiera [UNIFESP] (Amer Chemical Soc, 1973-01-01) -
Angiotensin-converting-enzyme inhibitors and angiotensin II receptor blockers for COVID-19: A living systematic review of randomized clinical trialsAngiotensin-converting-enzyme inhibitors and angiotensin II receptor blockers for COVID-19: A living systematic review of randomized clinical trials
Meza, Nicolás; Pérez-Bracchiglione, Javier; Pérez, Ignacio; Carvajal, Cristhian; Ortiz Muñoz, Luis Eugenio; Olguín, Pablo; Rada Giacaman, Gabriel Alejandro; Madrid, Eva (2021)Objective: This living systematic review aims to provide a timely, rigorous, and continuously updated summary of the evidence available on the role of angiotensin-converting enzyme inhibitors (ACEi) and angiotensin II ...