Article
The effect of removing potentially infectious dogs on the numbers of Canine Leishmania infantum Infections in an endemic area with high transmission rates
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GRIMALDI JR., Gabriel; TEVA, Antonio; SANTOS, Claudiney B.; FERREIRA, Adelson L.; FALQUETO, Aloísio. the effect of removing potentially infectious dogs on the numbers of Canine Leishmania infantum infections in an endemic area with high transmission rates. Am. J. Trop. Med. Hyg., San Francisco, CA, v. 86, n. 6, p. 966–971, 2012.
0002-9637
10.4269/ajtmh.2012.12-0040
Autor
Grimaldi Jr., Gabriel
Teva, Antonio
Santos, Claudiney B.
Ferreira, Adelson L.
Falqueto, Aloísio
Resumen
To assess the effect of the rapid removal of potentially infectious dogs on the prevalence and incidence of canine infections, a prospective study was undertaken in an area endemic for Leishmania infantum. We used serological testing based on the rapid DPP rK28 fusion protein chromatographic immunoassay for this dog screening-and-culling
intervention trial. The outcome was evaluated by measuring seropositivity and sero-conversion/-reversion rates for canine infection. Our estimates indicated that concomitant detection and elimination of seropositive dogs with active disease may affect the numbers of canine infections and disease burden temporarily, although it is insufficient as a measure to interrupt the zoonotic L. infantum transmission. However, most of the asymptomatic, seropositive dogs continuously exhibit low levels of antibodies and/or reverted, remaining seronegative thereafter. In the process of waiting for an effective vaccine, one option for canine reservoir control may be to identify these possibly genetically resistant animals and promote their expansion in the population.
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