Wound healing properties of Copaifera paupera in diabetic mice

dc.creatorAmorim, Jorge Luis
dc.creatorFigueiredo, Janaína de Barros
dc.creatorAmaral, Ana Claudia Fernandes
dc.creatorBarros, Eliane Gouvêa de Oliveira
dc.creatorPalmero, Célia
dc.creatorMpalantinos, Maria Athana
dc.creatorRamos, Aline de Souza
dc.creatorFerreira, José Luiz Pinto
dc.creatorSilva, Jefferson Rocha de Andrade
dc.creatorBenjamim, Claudia Farias
dc.creatorBasso, Silvia Luciane
dc.creatorNasciutti, Luiz Eurico
dc.creatorFernandes, Patricia Dias
dc.date2020-03-04T15:02:48Z
dc.date2020-03-04T15:02:48Z
dc.date2017
dc.date.accessioned2023-09-26T21:01:28Z
dc.date.available2023-09-26T21:01:28Z
dc.identifierAMORIM, Jorge Luis et al. Wound healing properties of Copaifera paupera in diabetic mice. PLoS One, v. 12, n. 10, p. 1-14, 2017.
dc.identifier1932-6203
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/40201
dc.identifier10.1371/journal.pone.0187380
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8867899
dc.descriptionCopaifera oleoresin is one of the most used natural products in popular medicine all over the world. Among other effects (i.e., anti-inflammatory, antinociceptive, microbicidal) one of the most well-known is its wound healing capacity. However, the mechanism by which the oleoresin presents its effect is still not clear. In this study, our aim was to evaluate the wound healing capacity of oleoresin obtained from Copaifera paupera, its mechanism of action and identify its major components. For these purposes, diabetic Swiss Webster mice were topically treated with oleoresin (100, 150 or 200 mg/kg) for 14 consecutive days after an excision was performed in the back of the mice. Cytokines, wound retraction and histological evaluation were conducted at 3, 7 and 10 days (for cytokines); 0, 3, 7, 10 and 14 days (for wound retraction); and 7 and 14 days (for histological evaluation). Our data indicate that oleoresin significantly reduced production of MCP-1 and TNF-α at days 7 and 10 post-excision and increased IL-10 production at both days. All treatments demonstrated an effect similar or higher to that in collagenase-treated mice. Histological evaluations demonstrated that higher dose treatment resulted in better resolution and closure of the wound and higher levels of collagen deposition and indexes of re-epithelialization even when compared with the collagenase-treated group. The treatment with oleoresin from Copaifera paupera demonstrated that it is even better than an ointment routinely used for improvement of wound healing, suggesting this oleoresin as an option for use in diabetic patients.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectWound healing properties
dc.subjectCopaifera paupera
dc.subjectDiabetic mice
dc.titleWound healing properties of Copaifera paupera in diabetic mice
dc.typeArticle


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