Human Gammaherpesvirus 8 Oncogenes Associated with Kaposi’s Sarcoma

dc.creatorLopes, Amanda de Oliveira
dc.creatorMarinho, Pedro do Nascimento
dc.creatorMedeiros, Letícia d’Ambrosio de Souza
dc.creatorPaula, Vanessa Salete de
dc.date2022-10-06T14:22:40Z
dc.date2022-10-06T14:22:40Z
dc.date2022
dc.date.accessioned2023-09-26T21:01:27Z
dc.date.available2023-09-26T21:01:27Z
dc.identifierLOPES, Amanda de Oliveira et al. Human Gammaherpesvirus 8 Oncogenes Associated with Kaposi’s Sarcoma. International Journal of Molecular Sciences, v. 23, 7203, p. 1 - 15, June 2022.
dc.identifier1422-0067
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/55016
dc.identifier10.3390/ ijms23137203
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8867896
dc.descriptionKaposi’s sarcoma-associated herpesvirus (KSHV), also known as human gammaherpesvirus 8 (HHV-8), contains oncogenes and proteins that modulate various cellular functions, including proliferation, differentiation, survival, and apoptosis, and is integral to KSHV infection and oncogenicity. In this review, we describe the most important KSHV genes [ORF 73 (LANA), ORF 72 (vCyclin), ORF 71 or ORFK13 (vFLIP), ORF 74 (vGPCR), ORF 16 (vBcl-2), ORF K2 (vIL-6), ORF K9 (vIRF 1)/ORF K10.5, ORF K10.6 (vIRF 3), ORF K1 (K1), ORF K15 (K15), and ORF 36 (vPK)] that have the potential to induce malignant phenotypic characteristics of Kaposi’s sarcoma. These oncogenes can be explored in prospective studies as future therapeutic targets of Kaposi’s sarcoma.
dc.formatapplication/pdf
dc.languageeng
dc.publisherMDPI
dc.rightsopen access
dc.subjectSarcoma de Kaposi
dc.subjectHerpesvírus associado ao sarcoma de Kaposi
dc.subjectOncogenes
dc.subjectKaposi’s sarcoma
dc.subjectKaposi’s sarcoma associated herpesvirus
dc.subjectOncogenes
dc.titleHuman Gammaherpesvirus 8 Oncogenes Associated with Kaposi’s Sarcoma
dc.typeArticle


Este ítem pertenece a la siguiente institución