Article

Human Gammaherpesvirus 8 Oncogenes Associated with Kaposi’s Sarcoma

Registro en:
LOPES, Amanda de Oliveira et al. Human Gammaherpesvirus 8 Oncogenes Associated with Kaposi’s Sarcoma. International Journal of Molecular Sciences, v. 23, 7203, p. 1 - 15, June 2022.
1422-0067
10.3390/ ijms23137203
Autor
Lopes, Amanda de Oliveira
Marinho, Pedro do Nascimento
Medeiros, Letícia d’Ambrosio de Souza
Paula, Vanessa Salete de
Institución
Resumen
Kaposi’s sarcoma-associated herpesvirus (KSHV), also known as human gammaherpesvirus 8 (HHV-8), contains oncogenes and proteins that modulate various cellular functions, including proliferation, differentiation, survival, and apoptosis, and is integral to KSHV infection and oncogenicity. In this review, we describe the most important KSHV genes [ORF 73 (LANA), ORF 72 (vCyclin), ORF 71 or ORFK13 (vFLIP), ORF 74 (vGPCR), ORF 16 (vBcl-2), ORF K2 (vIL-6), ORF K9 (vIRF 1)/ORF K10.5, ORF K10.6 (vIRF 3), ORF K1 (K1), ORF K15 (K15), and ORF 36 (vPK)] that have the potential to induce malignant phenotypic characteristics of Kaposi’s sarcoma. These oncogenes can be explored in prospective studies as future therapeutic targets of Kaposi’s sarcoma.
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