Article
AnEnPi: identification and annotation of analogous enzymes
Registro en:
OTTO, Thomas D. et al. AnEnPi: identification and annotation of analogous enzymes. BMC Bioinformatics, v. 9, n. 544, 9p, Dec. 2008.
1471-2105
10.1186/1471-2105-9-544
Autor
Otto, Thomas D.
Guimarães, Ana Carolina R.
Degrave, Wim M.
Miranda, Antonio B. de
Resumen
Enzymes are responsible for the catalysis of the biochemical reactions in metabolic
pathways. Analogous enzymes are able to catalyze the same reactions, but they present no
significant sequence similarity at the primary level, and possibly different tertiary structures as well.
They are thought to have arisen as the result of independent evolutionary events. A detailed study
of analogous enzymes may reveal new catalytic mechanisms, add information about the origin and
evolution of biochemical pathways and disclose potential targets for drug development.