HIV controllers with different viral load cut-off levels have distinct virologic and immunologic profiles

dc.creatorCôrtes, Fernanda H.
dc.creatorPassaes, Caroline P. B.
dc.creatorBello, Gonzalo
dc.creatorTeixeira, Sylvia L. M.
dc.creatorVorsatz, Carla
dc.creatorBabic, Dunja
dc.creatorSharkey, Mark
dc.creatorGrinsztejn, Beatriz
dc.creatorVeloso, Valdiléa G.
dc.creatorStenveson, Mario
dc.creatorMorgado, Mariza G.
dc.date2016-04-05T13:31:20Z
dc.date2016-04-05T13:31:20Z
dc.date2015
dc.date.accessioned2023-09-26T21:00:15Z
dc.date.available2023-09-26T21:00:15Z
dc.identifierCÔRTES, Fernanda H. et al. HIV controllers with different viral load cut-off levels have distinct virologic and immunologic profiles. Journal of Acquired Immune Deficiency Syndromes, v. 68, n. 4, p. 377–385, Apr. 2015.
dc.identifier1525-4135
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/13528
dc.identifier10.1097/QAI.0000000000000500
dc.identifier1944-7884
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8867564
dc.descriptionBackground—The mechanisms behind natural control of HIV replication are still unclear, and several studies pointed that elite controllers are a heterogeneous group. Methods—We performed analyses of virologic, genetic and immunologic parameters of HIV-1 controllers groups: 1) Elite Controllers (EC; VL <80 copies/mL); 2) Ebbing Elite Controllers (EEC; transient viremia/blips); and Viremic Controllers (VC; detectable viremia <5,000 copies/ mL). Untreated non-controllers (NC), patients under suppressive HAART and HIV-1 negative individuals were analyzed as controls. Results—Total and integrated HIV-1 DNA for EC were significantly lower than for NC and HAART groups. 2-LTR circles were detected in EEC (3/5) and VC (6/7) but not in EC. While EC and EEC maintain normal T cell counts over time, some VC displayed negative CD4+ T cells slopes. VC and EEC showed a higher percentage of activated CD8+ T cells and microbial translocation than HIV-1 negative controls. EC displayed a weaker Gag/Nef IFN-γ T cell response and a significantly lower proportion of anti-HIV IgG antibodies than EEC, VC and NC groups. Conclusion—Transient/persistent low level viremia in HIV controllers may have an impact on immunologic and virologic profiles. Classify HIV controllers patients taking into account their virologic profile may decrease the heterogeneity of HIV controllers cohorts, which may help to clarify the mechanisms associated to the elite control of HIV.
dc.formatapplication/pdf
dc.languageeng
dc.publisherLippincott, Williams & Wilkins
dc.rightsopen access
dc.subjectHIV-1
dc.subjectElite controllers
dc.subjectViral load blips
dc.subjectOngoing replication
dc.subjectImmune activation
dc.subjectImmune response
dc.subjectMicrobial translocation
dc.subjectHIV-1
dc.subjectCarga viral
dc.subjectReplicon
dc.titleHIV controllers with different viral load cut-off levels have distinct virologic and immunologic profiles
dc.typeArticle


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