Article
Inducible nitric oxide synthase (iNOS) expression in monocytes during acute Dengue Fever in patients and during in vitro infection
Registro en:
SOUZA, Patríicia C. F. Neves et al. Inducible nitric oxide synthase (iNOS) expression in monocytes during acute Dengue Fever in patients and during in vitro infection. BMC Infectious Diseases, v. 5, n. 64, p. 1-12, 2005.
1471-2334
10.1186/1471-2334-5-64
Autor
Souza, Patrícia C. F. Neves
Azeredo, Elzinandes L.
Zagne, Sonia M. O.
Souza, Rogério Valls de
Reis, Sonia R. N. I.
Cerqueira, Denise I. S.
Nogueira, Rita M. R.
Kubelka, Claire F.
Resumen
Mononuclear phagocytes are considered to be main targets for Dengue Virus (DENV) replication. These cells are activated after infection, producing proinflammatory mediators, including tumournecrosis factor-α, which has also been detected in vivo. Nitric oxide (NO), usually produced by
activated mononuclear phagocytes, has antimicrobial and antiviral activities.