Thymus atrophy and double-positive escape are common features in infectious diseases

dc.creatorMeis, Juliana de
dc.creatorOliveira, Désio Aurélio Farias de
dc.creatorPanzenhagen, Pedro H. Nunes
dc.creatorMaran, Naiara
dc.creatorVilla-Verde, Déa Maria Serra
dc.creatorMorrot, Alexandre
dc.creatorSavino, Wilson
dc.date2017-04-18T16:48:52Z
dc.date2017-04-18T16:48:52Z
dc.date2012
dc.date.accessioned2023-09-26T20:56:12Z
dc.date.available2023-09-26T20:56:12Z
dc.identifierMEIS, Juliana de: et al. Thymus Atrophy and Double-Positive Escape Are Common Features in Infectious Diseases. Journal of Parasitology Research, Volume 2012, Article ID 574020, 9p, 2012.
dc.identifier2090-0023
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/18501
dc.identifier10.1155/2012/574020
dc.identifier2090-0031
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8866444
dc.descriptionThe thymus is a primary lymphoid organ in which bone marrow-derived T-cell precursors undergo differentiation, leading to migration of positively selected thymocytes to the T-cell-dependent areas of secondary lymphoid organs. This organ can undergo atrophy, caused by several endogenous and exogenous factors such as ageing, hormone fluctuations, and infectious agents. This paper will focus on emerging data on the thymic atrophy caused by infectious agents. We present data on the dynamics of thymus lymphocytes during acute Trypanosoma cruzi infection, showing that the resulting thymus atrophy comprises the abnormal release of thymic-derived T cells and may have an impact on host immune response.
dc.formatapplication/pdf
dc.languageeng
dc.publisherHindawi Publishing Corporation
dc.rightsopen access
dc.subjectTimo
dc.subjectTrypanosoma cruzi
dc.subjectInfecção
dc.subjectAtrofia do Timo
dc.subjectLinfócitos do timo
dc.subjectThymus
dc.subjectThymus Atrophy
dc.subjectTrypanosoma cruzi infection
dc.subjectthymus lymphocytes
dc.titleThymus atrophy and double-positive escape are common features in infectious diseases
dc.typeArticle


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