Article
Plasmodium vivax metacaspase 1 (PvMCA1) catalytic domain is conserved in field isolates from Brazilian Amazon
Registro en:
SOUZA, Hugo Amorim dos Santos de et al. Plasmodium vivax metacaspase 1 (PvMCA1) catalytic domain is conserved in field isolates from Brazilian Amazon. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 116, e200584, 6 p, May 2021.
0074-0276
10.1590/0074-02760200584
1678-8060
Autor
Souza, Hugo Amorim dos Santos de
Escafa, Victor Fernandes
Blanco, Carolina Moreira
Baptista, Carolina Moreira
Barros, Jenifer Peixoto
Riccio, Evelyn Ketty Pratt
Rodrigues, Aline Beatriz Mello
Melo, Gisely Cardoso de
Lacerda, Marcus Vinícius Guimarães de
Souza, Rodrigo Medeiros de
Lima Junior, Josué da Costa
Guimarães, Ana Carolina Ramos
Mota, Fabio Faria da
Silva, João Hermínio Martins da
Ribeiro, Cláudio Tadeu Daniel
Pratt-Riccio, Lilian Rose
Totino, Paulo Renato Rivas
Resumen
In the present study, we investigated the genetic diversity of Plasmodium vivax metacaspase 1 (PvMCA1) catalytic domain in
two municipalities of the main malaria hotspot in Brazil, i.e., the Juruá Valley, and observed complete sequence identity among
all P. vivax field isolates and the Sal-1 reference strain. Analysis of PvMCA1 catalytic domain in different P. vivax genomic
sequences publicly available also revealed a high degree of conservation worldwide, with very few amino acid substitutions
that were not related to putative histidine and cysteine catalytic residues, whose involvement with the active site of protease was
herein predicted by molecular modeling. The genetic conservation presented by PvMCA1 may contribute to its eligibility as a
druggable target candidate in vivax malaria.
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