Article
Plasmodium vivax Infection Impairs Regulatory T-Cell Suppressive Function During Acute Malaria
Registro en:
COSTA, Pedro Augusto Carvalho et al. Plasmodium vivax Infection Impairs Regulatory T-Cell Suppressive Function During Acute Malaria. J Infect Dis., v. 218, n. 8, p. 1314-1323, 2018
0022-1899
10.1093/infdis/jiy296
Autor
Costa, Pedro Augusto Carvalho
Figueiredo, Maria Marta
Diniz, Suelen Queiroz
Marino, Ana Paula Maia Peixoto
Maloy, Kevin J
Carvalho, Andrea Teixeira de
Tada, Mauro Shugiro
Pereira, Dhelio Batista
Gazzinelli, Ricardo Tostes
Antonelli, Lis Ribeiro do Valle
Resumen
The balance between pro- and antiinflammatory mechanisms is essential to limit immune-mediated pathology, and CD4+ forkhead box P3 (Foxp3+) regulatory T cells (Treg) play an important role in this process. The expression of inhibitory receptors regulates cytokine production by Plasmodium vivax-specific T cells. Our goal was to assess the induction of programmed death-1 (PD-1) and cytotoxic T-lymphocyte antigen (CTLA-4) on Treg during malaria and to evaluate their function. We found that P. vivax infection triggered an increase in circulating Treg and their expression of CTLA-4 and PD-1. Functional analysis demonstrated that Treg from malaria patients had impaired suppressive ability and PD-1+Treg displayed lower levels of Foxp3 and Helios, but had higher frequencies of T-box transcription factor+ and interferon-gamma+ cells than PD-1-Treg. Thus malaria infection alters the function of circulating Treg by triggering increased expression of PD-1 on Treg that is associated with decreased regulatory function and increased proinflammatory characteristics 2025-01-01