A Potential Role for Mononuclear Phagocytes in Cutaneous Ulcer Development in Human Immunodeficiency Virus-Leishmania braziliensis Coinfection

dc.creatorGuimarães, Luiz Henrique Santos
dc.creatorSaldanha, Maíra
dc.creatorMenezes, Taís
dc.creatorMoreno, Lis
dc.creatorTorres, Alex José Leite
dc.creatorCosta, Rúbia Suely Santana
dc.creatorPassos, Sara Timoteo
dc.creatorBadaró, Roberto José da Silva
dc.creatorArruda, Sérgio Marcos
dc.creatorCarvalho, Lucas Pedreira de
dc.date2017-07-19T17:56:32Z
dc.date2017-07-19T17:56:32Z
dc.date2015
dc.date.accessioned2023-09-26T20:49:17Z
dc.date.available2023-09-26T20:49:17Z
dc.identifierGUIMARÃES, L. H. S. et al. A Potential Role for Mononuclear Phagocytes in Cutaneous Ulcer Development in Human Immunodeficiency Virus-Leishmania braziliensis Coinfection. American Journal of Tropical Medicine and Hygiene, v. 93, n. 6, p. 1219–1223. 2015.
dc.identifier0002-9637
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/20150
dc.identifier10.4269/ajtmh.14-0475
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8864481
dc.descriptionNational Institute of Health (AI088650) and the Brazilian Council for research (CNPq).
dc.descriptionSkin ulcer development in cutaneous leishmaniasis due to Leishmania braziliensis infection is associated with a mononuclear cell infiltrate and high levels of tumor necrosis factor (TNF). Herein, we show that despite the absence of Leishmania-driven TNF, a cutaneous leishmaniasis patient with acquired immunodeficiency syndrome developed a skin ulcer. The presence of mononuclear phagocytes and high levels of TNF, chemokine (C-C motif) ligand 2 (CCL2), and metalloproteinase-9 in tissue are identified as potential contributors to immunopathology observed in L. braziliensis-infected patients.
dc.formatapplication/pdf
dc.languageeng
dc.publisherAmerican Society of Tropical Medicine and Hygiene
dc.rightsopen access
dc.subjectLeishmania braziliensis
dc.subjectLeishmaniose Cutânea
dc.subjectInfecções por HIV
dc.subjectFator de Necrose Tumoral alfa
dc.subjectÚlcera da pele
dc.subjectHumanos
dc.subjectInfecção
dc.subjectFagocitose
dc.subjectLeishmania braziliensis
dc.subjectLeishmaniasis, Cutaneous
dc.subjectHIV Infections
dc.subjectTumor Necrosis Factor-alpha
dc.subjectSkin Ulcer
dc.subjectHumans
dc.subjectCoinfection
dc.subjectPhagocytosis
dc.titleA Potential Role for Mononuclear Phagocytes in Cutaneous Ulcer Development in Human Immunodeficiency Virus-Leishmania braziliensis Coinfection
dc.typeArticle


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