Article
Evidences for leishmanicidal activity of the naphthoquinone derivative epoxy-α-lapachone
Registro en:
SILVA, Franklin Souza et al. Evidences for leishmanicidal activity of the naphthoquinone derivative epoxy-α-lapachone. Experimental Parasitology, v.147, p.81–84, 2014.
0014-4894
10.1016/j.exppara.2014.10.002
Autor
Silva, Franklin Souza
Nascimento, Samara Braga do
Bourguignon, Saulo Cabral
Pereira, Bernardo Acácio Santini
Carneiro, Paula Fernandes
Silva, Wellington Seguis da
Alves, Carlos Roberto
Pinho, Rosa Teixeira de
Resumen
In this work, we analyze the leishmanicidal effects of epoxy-α-lapachone on Leishmania (Viannia) braziliensis
and Leishmania (Leishmania) amazonensis. Promasigotes and amastigotes (inhabiting human macrophages)
from both species were assayed to verify the compound’s activity over the distinct morphological
stages. The incubation with epoxy-α-lapachone led to a significant decrease in the numbers of promastigotes
from both species in the cultures, in a dose-and time-dependent fashion. The survival of amastigotes inhabiting
human macrophages was also drastically affected by the compound, as shown by the variations
in the endocytic index. Our results indicate that the epoxy-α-lapachone has an antiparasitic effect over
Leishmania in both morphological stages and may potentially affect a range of species in two distinct subgenera
of this parasite.
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