Patent
Polypeptide with Asparaginase Activity, Expression Cassette, Expression Vector, Host Cell, Pharmaceutical Composition, Methods for Producing a Polypeptide with Asparaginase Activity and for Preventing or Treating Cancer, and Use of a Polypeptide
Registro en:
SOUZA, Tatiana de Arruda Campos Brasil et al. Polypeptide with asparaginase activity, expression cassette, expression vector, host cell, pharmaceutical composition, methods for producing a polypeptide with asparaginase activity and for preventing or treating cancer, and use of a polypeptide. US Pat. 2021/0121544 A1, 29 abr. 2021. 31p.
Fundação Oswaldo Cruz
A61K 38/50
C12N 15/66
A61P 35/02
US16/963,173
BR102018001033-6A2
US2021/0121544A1
Autor
Souza, Tatiana de Arruda Campos Brasil de
Zanchin, Nilson Ivo Tonin
Morais, Stephanie Bath de
Resumen
The present invention refers to polypeptides with asparaginase activity that have an increased rate of self-processing compared to human wild L-asparaginase (ASRGL1), with mutation in the ASRGL1 glycine rich loop called HGG loop (Histidine 8-Glycine 9-Glycine 10). Polynucleotides that encode the polypeptides of invention are also described here, expression cassettes comprising so-called polynucleotides, expression vectors, host cells, pharmaceutical compositions, uses of the invention polypeptide in the manufacture of a preventive medicine or cancer treatment and methods to produce the polypeptide of invention and to prevent or treat cancer. Brasil Organização Mundial para Propriedade Intelectual OMPI China Escritório de Patentes Europeu Estados Unidos da América Índia Canadá