Article
The Association of the Fat Mass and Obesity-Associated Gene (FTO) rs9939609 Polymorphism and the Severe Obesity in a Brazilian Population
Registro en:
FONSECA, Ana Carolina Proença da et al. The association of the fat mass and obesity-associated gene (FTO) rs9939609 polymorphism and the severe obesity in a Brazilian population. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, v. 12, p. 667-684, 2019.
1178-7007
10.2147/DMSO.S199542. eCollection 2019
Autor
Fonseca, Ana Carolina Proença da
Abreu, Gabriella de Medeiros
Zembrzuski, Veronica Marques
Campos Junior, Mario
Carneiro, João Regis Ivar
Nogueira Neto, José Firmino
Cabello, Giselda Maria Kalil
Cabello, Pedro Hernán
Resumen
Obesity occurs due to the interaction between the genetic background and
environmental factors, including an increased food intake and a sedentary lifestyle.
Nowadays, it is clear that there is a specific circuit, called leptin-melanocortin pathway,
which stimulates and suppresses food intake and energy expenditure. Therefore, the aim of
this study was to evaluate the influence of genetic variants related to appetite regulation and
energy expenditure on severe obesity susceptibility and metabolic phenotypes in a Brazilian
cohort.