Article
Association between MBL2 haplotypes and dengue severity in children from Rio de Janeiro, Brazil
Registro en:
ORNELAS, Alice Maria de Magalhães et al. Association between MBL2 haplotypes and dengue severity in children from Rio de Janeiro, Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 114, p. 1-7, 2019.
0074-0276
10.1590/0074-02760190004
1678-8060
Autor
Ornelas, Alice Maria de Magalhães
Xavier-de-Carvalho, Caroline
Alvarado-Arnez, Lucia Elena
Ribeiro-Alves, Marcelo
Rossi, Átila Duque
Tanuri, Amilcar
Aguiar, Renato Santana
Moraes, Milton Ozório
Cardoso, Cynthia Chester
Resumen
BACKGROUND: Dengue is an arthropod-borne viral disease with a majority of asymptomatic individuals and clinical manifestations varying from mild fever to severe and potentially lethal forms. An increasing number of genetic studies have outlinedthe association between host genetic variations and dengue severity. Genes associated to viral recognition and entry, as well as those encoding mediators of the immune response against infection are strong candidates for association studies. OBJECTIVES: The aim of this study was to investigate the association between MBL2, CLEC5A, ITGB3 and CCR5 genes and dengue severity in children. METHODS: A matched case-control study was conducted and 19 single nucleotide polymorphisms (SNPs) were investigated. FINDINGS: No associations were observed in single SNP analysis. However, when MBL2 SNPs were combined in haplotypes, the allele rs7095891G/rs1800450C/ rs1800451C/rs4935047A/rs930509G/rs2120131G/rs2099902C was significantly associated to risk of severe dengue under α = 0.05 (aOR = 4.02; p = 0.02). A second haplotype carrying rs4935047G and rs7095891G alleles was also associated to risk (aOR = 1.91; p = 0.04). MAIN CONCLUSIONS: This is the first study to demonstrate the association between MBL2 haplotypes and dengue severity in Brazilians including adjustment for genetic ancestry. These results reinforce the role of mannose binding lectin in immune response to DENV.