Article
Experimental chronic Chagas' disease myocarditis is an autoimmune disease preventable by induction of immunological tolerance to myocardial antigens.
Registro en:
PONTES-DE-CARVALHO, L. et al. Experimental chronic Chagas' disease myocarditis is an autoimmune disease preventable by induction of immunological tolerance to myocardial antigens. Journal of Autoimmunity, v. 18, n. 2, p. 131-8, mar. 2002.
0896-8411
Autor
Pontes-de-Carvalho, Lain Carlos
Santana, Cláudia Dias de
Soares, Milena Botelho Pereira
Oliveira, Geraldo Gileno de Sá
Cunha Neto, Edecio
Santos, Ricardo Ribeiro dos
Resumen
The protozoan Trypanosoma cruzi causes chronic Chagas’ disease myocarditis
(CCDM) in infected mammals. The pathogenesis of CCDM, however, is still
unclear. Indirect evidence for either parasite- or heart-specific immune
responses playing a pathogenic role is available. In this work, the participation
of autoimmunity in the development of CCDM is demonstrated in mice in
which immunological tolerance to heart antigens was induced or strengthened
prior to their infection by T. cruzi. Tolerance was induced by heart antigen
administration in the presence of complete Freund’s adjuvant and anti-CD4
antibodies. Tolerized mice developed less intense CCDM than control nontolerized
animals that had received only anti-CD4 and adjuvant. This result
confirms the important notion that tolerance to self, and in particular to heart
antigens, may be reinforced/induced in normal animals, and raises the
possibility that analogous interventions may prevent the development of
CCDM in millions of T. cruzi-infected human beings.
Materias
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Evaluation of memory immune response to mycobacterium extract among household contact of tuberculosis cases
Cavalcanti, Y. V. N.; Pereira, V. R. A.; Reis, L. C.; Ramos, A. L. G.; Luna, C. F.; Nascimento, E. J. M.; Lucena-Silva, N. -
Mucosal and systemic anti-GAG immunity induced by neonatal immunization with HIV LAMP/gag DNA vaccine in mice
Goldoni, Adriana Letícia; Maciel, Milton; Rigato, Paula Ordonhez; Piubelli, Orlando; Brito, Cyro Alves de; Melo, Andrea; Marques, Ernesto Torres; August, Joseph Thomas; Duarte, Alberto José da Silva; Sato, Maria Notomi -
A study on the immunological basis of the dissociation between type I-hypersensitivity skin reactions to Blomia tropicalis antigens and serum anti-B. tropicalis IgE antibodies.
Ponte, João Carlos Marques; Junqueira, Samuel Badaró; Veiga, Rafael Valente; Barreto, Maurício Lima; Pontes-de-Carvalho, Lain Carlos; Neves, Neuza Maria Alcântara