INFLUENCIA DO ACRESCIMO DE MANITOL A SOLUCAO NUTRIENTE NO DESEMPENHO MECANICO E NO GRAU DE EDEMA MIOCARDICO DE CORACOES ISOLADOS DE RATOS

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorZornoff, Leonardo Antonio Mamede
dc.creatorPaiva, Sergio Alberto Rupp de
dc.creatorTrovanelli Tornero, M. T.
dc.creatorStateri Carvalho, M. S.
dc.creatorFerreira Tucci, P. J.
dc.date2014-05-27T11:17:59Z
dc.date2016-10-25T18:13:26Z
dc.date2014-05-27T11:17:59Z
dc.date2016-10-25T18:13:26Z
dc.date1995-01-01
dc.date.accessioned2017-04-06T00:45:48Z
dc.date.available2017-04-06T00:45:48Z
dc.identifierArquivos Brasileiros de Cardiologia, v. 64, n. 3, p. 225-229, 1995.
dc.identifier0066-782X
dc.identifierhttp://hdl.handle.net/11449/64560
dc.identifierhttp://acervodigital.unesp.br/handle/11449/64560
dc.identifier2-s2.0-0029079165.pdf
dc.identifier2-s2.0-0029079165
dc.identifierhttp://www.arquivosonline.com.br/pesquisartigos/Pdfs/1995/V64N3/64030009.pdf
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/886378
dc.descriptionPurpose - To analyse the influence of mannitol added to Krebs-Henseleit (KH) solution on the myocardium edema and myocardial function. Methods - Isolated rat heart under isovolumetric contractions studied according to Langendorff's technique were perfused with KH solution at constant flow during 90 min. The coronary perfusion pressure, diastolic and systolic pressures were recorded at every 15 min. At the end of the experiment, myocardium water content was measured in hearts perfused with KH solution (group I, n = 9) and in hearts perfused with KH solution plus 8 mM mannitol (group II, n = 8). These results were compared to non-perfused control heart (n = 9). Results - Myocardial water content was statistically higher in group I (80.8 ± 1.3%) compared to group II (78.1 ± 0.7%) and control group (75.5 ± 0.5%). Systolic arterial pressure was statistically higher in group I (86.2 ± 11.5 mmHg) compared to group II (72.7 ± 21.1 mmHg). There was no difference in the diastolic pressure between the two groups. Coronary perfusion pressure (Pp) increased progressively during the experiment in both groups. However, Pp was lower in group II than in group I. Conclusion - Mannitol added to KH solution significantly attenuates the myocardium edema in the isolated perfused rat heart.
dc.languagepor
dc.relationArquivos Brasileiros de Cardiologia
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectmannitol
dc.subjectmyocardial-edema
dc.subjectcardioplegic agent
dc.subjectglucose
dc.subjectkrebs henseleit solution
dc.subjectKrebs-Henseleit solution
dc.subjectosmotic diuretic agent
dc.subjecttrometamol
dc.subjectanimal tissue
dc.subjectcontrolled study
dc.subjectcoronary reperfusion
dc.subjectedema
dc.subjectheart function
dc.subjectmyocardial disease
dc.subjectnonhuman
dc.subjectrat
dc.subjectanimal
dc.subjectblood pressure
dc.subjectbody water
dc.subjectcomparative study
dc.subjectdrug effect
dc.subjectheart contraction
dc.subjectheart edema
dc.subjectin vitro study
dc.subjectmale
dc.subjectmultivariate analysis
dc.subjectpathophysiology
dc.subjectrat strain
dc.subjectAnimal
dc.subjectBlood Pressure
dc.subjectBody Water
dc.subjectCardioplegic Solutions
dc.subjectComparative Study
dc.subjectDiuretics, Osmotic
dc.subjectEdema, Cardiac
dc.subjectEnglish Abstract
dc.subjectGlucose
dc.subjectIn Vitro
dc.subjectMale
dc.subjectMannitol
dc.subjectMultivariate Analysis
dc.subjectMyocardial Contraction
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectTromethamine
dc.titleINFLUENCIA DO ACRESCIMO DE MANITOL A SOLUCAO NUTRIENTE NO DESEMPENHO MECANICO E NO GRAU DE EDEMA MIOCARDICO DE CORACOES ISOLADOS DE RATOS
dc.typeOtro


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