Article
Maternal schistosomiasis: IL-2, IL-10 and regulatory T lymphocytes to unrelated antigen in adult offspring mice
Registro en:
FERNANDES, E. de S. et al. Maternal Schistosomiasis: IL-2, IL-10 and Regulatory T Lymphocytes to Unrelated Antigen in Adult Offspring Mice. Revista da Sociedade Brasileira de Medicina Tropical, v. 51, n. 4, p. 546–549, ago. 2018.
1678-9849
10.1590/0037-8682-0338-2016
Autor
Fernandes, Erica de Souza
Lorena, Virgínia Maria de Barros
Sales, Iana Rafaela Fernandes
Albuquerque, Mônica Camelo Pessoa de Azevedo
Gomes, Yara de Miranda
Costa, Vlaudia Maria Assis
Souza, Valdênia Maria Oliveira de
Resumen
INTRODUCTION: We evaluated IL-10, IL-2 and regulatory T cells (Treg), in response to ovalbumin (OA), in offspring from schistosomotic mouse mothers. METHODS: We used animals born (BIM) or suckled (SIM) from infected mothers; and mice born/suckled from infected (BSIM) or non-infected mothers (CONTROL). After OA+adjuvant immunization, spleen cells were cultured, with or without OA, and doubly marked for cytometry.
RESULTS: BIM showed fewer CD4+/IL-2+ and more B220+/IL-10+ cells, whereas the SIM group showed increased Treg frequency. BSIM had fewer B220+/IL-10+ and Treg cells. CONCLUSIONS: Separately, gestation or nursing induced immunosuppressive cells in infected mothers, but improved anti-OA immunity when combined.
Materias
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