Otro
Toxicologic evaluation of acute and subacute oral administration of Cucurbita maxima seed extracts to rats and swine
Registro en:
Journal of Ethnopharmacology, v. 43, n. 1, p. 45-51, 1994.
0378-8741
10.1016/0378-8741(94)90115-5
2-s2.0-0028363013
Autor
Queiroz-Neto, Antonio de
Mataqueiro, Maria Isabel
Santana, Aureo Evangelista
Alessi, Antonio Carlos
Resumen
The extract prepared from dried seeds of Cucurbita maxima was administered to rats and pigs. Following a single dose or 4 weeks of daily oral administration, the extract produced no changes in serum glucose, urea, creatinine, total protein, uric acid, GOT, GPT, LDH or blood counts. Urine analysis (urea, uric acid, creatinine, total protein, Na and K), as well as histopathological investigation, showed no abnormalities. These results taken as a whole indicate that the seeds of C. maxima as used in Brazilian folk medicine are not toxic for rats and swine.
Materias
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