Leishmania infection in blood donors: a new challenge in leishmaniasis transmission?

dc.creatorFrança, Adriana de Oliveira
dc.creatorPompilio, Mauricio Antonio
dc.creatorPontes, Elenir Rose Jardim Cury
dc.creatorOliveira, Márcia Pereira de
dc.creatorPereira, Luiza Oliveira Ramos
dc.creatorLima, Rosimar Baptista
dc.creatorGoto, Hiro
dc.creatorSanchez, Maria Carmen Arroyo
dc.creatorFujimori, Mahyumi
dc.creatorLima Júnior, Manoel Sebastião da Costa
dc.creatorMatos, Maria de Fatima Cepa
dc.creatorDorval, Maria Elizabeth Moraes Cavalheiros
dc.date2019-04-26T14:19:01Z
dc.date2019-04-26T14:19:01Z
dc.date2018
dc.date.accessioned2023-09-26T20:44:57Z
dc.date.available2023-09-26T20:44:57Z
dc.identifierFRANÇA, Adriana de Oliveira et al. Leishmania infection in blood donors: a new challenge in leishmaniasis transmission? PLoS ONE, v. 13, n. 6, p. 1-13, 14 June 2018.
dc.identifier1932-6203
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/32779
dc.identifier10.1371/journal.pone.0198199
dc.identifier1932-6203
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8863174
dc.descriptionFundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul (Fundect), http://fundect.ledes.net/, termos de outorga n˚ 0191/12, SIAFEM:020919, Processo: 23/200.686/2012 (to MAP) and n˚ 114/2014, SIAFEM:023670, Processo: 23/200.262.
dc.descriptionTransfusion-transmitted leishmaniasis has been a concern in regions endemic for the disease. Whether immediate or delayed, the risks posed by this mode of transmission call for careful assessment. The purpose of this study was to detect Leishmania infection in blood donors living in an endemic area and to investigate progression to the disease in these individuals. Immunofluorescent antibody test, enzyme-linked immunosorbent assay, leishmaniasis rapid test, and the polymerase chain reaction were applied to 430 donors in an initial evaluation. Of those donors with at least one positive test, 50 were reevaluated four years later by the same methods, as were 25 controls who had been negative on the same tests. In the first evaluation, Leishmania infection was detected in 41.4% (95% CI: 36.7–46.1) of donors (n = 430). None of the 75 reevaluated individuals had developed the disease, but retesting revealed positivity in at least one test in 36.0% (95% CI: 25.1–46.9) of donors. Of the 50 initially testing positive, 50% remained so on retesting. Of the 25 initially negative controls, two tested positive in the subsequent evaluation. The severity of the parasitosis and the risk of transfusion transmission warrant investigation of the potential inclusion of methods for Leishmania detection into blood banks for effective screening of infected donors.
dc.formatapplication/pdf
dc.languageeng
dc.publisherPublic Library of Science
dc.rightsopen access
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectBlood Donors
dc.subjectBlood Safety/methods
dc.subjectDonor Selection/methods
dc.subjectEnzyme-Linked Immunosorbent Assay
dc.subjectFemale
dc.subjectHumans
dc.subjectLeishmania
dc.subjectLeishmaniasis/blood
dc.subjectLeishmaniasis/transmission
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectAdolescente
dc.subjectAdulto
dc.subjectEnvelhecido
dc.subjectDoadores de Sangue
dc.subjectSegurança do Sangue / métodos
dc.subjectSeleção de Doadores / métodos
dc.subjectEnsaio de Imunoadsorção Enzimática
dc.subjectFêmea
dc.subjectHumanos
dc.subjectLeishmania
dc.subjectLeishmaniose / sangue
dc.subjectLeishmaniose / transmissão
dc.subjectMasculino
dc.subjectMeia idade
dc.titleLeishmania infection in blood donors: a new challenge in leishmaniasis transmission?
dc.typeArticle


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