Production of septal fibrosis of the liver by means of foreign protein injections into rats.

dc.creatorGotardo, Bruna Magalhães
dc.creatorAndrade, Rodrigo Guimarães
dc.creatorOliveira, Ludmila Fernandes
dc.creatorAndrade, Zilton de Araújo
dc.date2012-03-28T21:35:37Z
dc.date2012-03-28T21:35:37Z
dc.date2003
dc.date.accessioned2023-09-26T20:44:54Z
dc.date.available2023-09-26T20:44:54Z
dc.identifierGOTARDO, B.M. et al. Production of septal fibrosis of the liver by means of foreign protein injections into rats. Revista da Sociedade Brasileira de Medicina Tropical de São Paulo, v. 36, n. 5, p. 577-80, set./out. 2003.
dc.identifier0037-8682
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/3821
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8863159
dc.descriptionPara se investigar o potencial fibrogênico de materiais derivados da Capillaria hepatica foi feita uma tentativa para se induzir fibrose hepática septal em ratos, através de injeções intraperitoneais repetidas de um extrato de fígado de camundongo infectado pela Capillaria hepática. Dois dos 10 ratos assim tratados desenvolveram fibrose. Comparativamente, 4 dos 9 ratos que receberam injeções de soro de porco desenvolveram fibrose septal do fígado, enquanto nenhuma fibrose apareceu em 10 ratos tratados com extratos de fígado normal de camundongo. Uma vez que, na infecção natural de ratos pela Capillaria hepatica, a fibrose aparece em 100% dos casos, fica evidente que a administração intraperitoneal de uma substância não revela inteiramente o seu potencial fibrogênico
dc.descriptionSimilarities and differences in antigenic humoral responses and electrophoretic patterns between Capillaria hepatica and pig-serum were investigated as a contribution to the understanding of hepatic fibrosis induced by the parenteral administration of foreign proteins. Only two out of 10 rats receiving repeated intraperitoneal injections of an extract of Capillaria hepatica-infected mouse liver presented septal hepatic fibrosis (20%). Under the same experimental conditions, 4 out of 9 rats (44.4%) developed septal fibrosis following whole pig-serum administration. Injections of normal mouse liver extracts did not result in hepatic fibrosis. Since a 100% septal fibrosis rate is observed in experimentally Capillaria hepatica-infected rats, it appeared that Capillaria hepatica products continuously released from inside the liver creates a much more effective fibrosis inducing mechanism than the parenteral administration of such factors. Thus, repeated peritoneal administration of a foreign protein to rats would not reveal the full fibrogenic potential it may have under natural conditions.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectCapillaria hepatica
dc.subjectModelo do soro de porco
dc.subjectFibrose septal hepática
dc.subjectCapillaria
dc.subjectProteínas de Helminto
dc.subjectCirrose Hepática Experimental
dc.subjectHepatopatias Parasitárias
dc.subjectCapillaria
dc.subjectModelos Animais de Doenças
dc.subjectCirrose Hepática Experimental
dc.subjectHepatopatias Parasitárias
dc.subjectCamundongos
dc.subjectRatos Wistar
dc.titleProduction of septal fibrosis of the liver by means of foreign protein injections into rats.
dc.typeArticle


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