Article
Lymphocyte subset reference intervals in blood donors from northeastern Brazil
Registro en:
TORRES, A. J. L. et al. Lymphocyte subset reference intervals in blood donors from northeastern Brazil. Anais da Academia Brasileira de Ciências, v. 87, n. 2, p. 1019-1025, 2015.
0001-3765
Autor
Torres, Alex José Leite
Cisneiros, Patricia
Guedes, Rosa
Grassi, Maria Fernanda Rios
Meyer, Roberto José
Bendicho, Maria Teresita
Lopes, Tais Gardenia Santos Lemos
Félix, Gabriela
Martins Netto, Eduardo
Brites, Carlos
Abe-Sandes, Kiyoko
Brandão, Claudio
Neves, Neuza Maria Alcântara
Freire, Songeli Menezes
Resumen
The reference intervals for leukocytes and lymphocytes currently used by most clinical laboratories present
limitations as they are primarily derived from individuals of North American and European origin. The
objective this study was to determine reference values for peripheral blood B lymphocytes, T lymphocyte
subsets (CD4+, CD8+, naïve, memory, regulatory, TCRαβ and TCRγδ+) and NK cells from blood donors
in Salvador-Bahia, Brazil. Results: The proportion of included male subjects was 73.7% and the median ages of males (34) and females (35) were found to be similar. Absolute counts total lymphocytes subsets to
both gender was 1,956 (1,060-4,186) cells and relative values 34%. The T CD4+ and T CD8+ lymphocytes
relative values was 51% (20-62) and 24% (9-28), respectively. The most statistically significant finding
observed was a higher percentage of B lymphocytes (p=0.03) in females. Commonly cited subset reference
intervals were found to be consistent with values in several populations from different geographic areas.