Immunological tolerance to pig-serum partially inhibits the formation of septal fibrosis of the liver in Capillaria hepatica-infected rats.

dc.creatorAndrade, Rodrigo Guimarães
dc.creatorGotardo, Bruna Magalhães
dc.creatorAssis, Bárbara Cristina Alves de
dc.creatorMengele Junior, José Orivaldo
dc.creatorAndrade, Zilton de Araújo
dc.date2011-10-04T20:58:54Z
dc.date2011-10-04T20:58:54Z
dc.date2005
dc.date.accessioned2023-09-26T20:44:28Z
dc.date.available2023-09-26T20:44:28Z
dc.identifierANDRADE, R. G. et al. Immunological tolerance to pig-serum partially inhibits the formation of septal fibrosis of the liver in Capillaria hepatica-infected rats. Memórias do Instituto Oswaldo Cruz, v. 99, n. 7, p. 703-707, nov. 2004.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/3250
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8863022
dc.descriptionSysthematized septal fibrosis of the liver can be induced in rats either by repeated intraperitoneal injections of pig-serum or by Capillaria hepatica infection. The relationship between these two etiological factors, as far as hepatic fibrosis is concerned, is not known, and present investigation attempts to investigate it. C. hepatica-induced septal fibrosis of the liver was considerably inhibited in rats previously rendered tolerant to pig-serum. Pig-serum-tolerant rats developed antibodies against pig-serum when infected with C. hepatica, but this did not happen when the infection occurred in normal rats. On the other hand, anti-C. hepatica antibodies failed to recognize any epitope in pig-serum, by Western blot. However, no evidence of an immunological cross reactivity was found, at least at the humoral level. Alternatively, cell-mediated mechanisms may be involved, and further investigations are warranted.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectPig-serum model
dc.subjectCapillaria hepatica
dc.subjectHepatic septal fibrosis
dc.subjectAnticorpos Anti-Helmínticos
dc.subjectAntígenos de Helmintos
dc.subjectCapillaria
dc.subjectInfecções por Enoplida
dc.subjectTolerância Imunológica
dc.subjectCirrose Hepática Experimental
dc.subjectHepatopatias Parasitárias
dc.subjectWestern Blotting
dc.subjectRatos Wistar
dc.subjectELISA
dc.titleImmunological tolerance to pig-serum partially inhibits the formation of septal fibrosis of the liver in Capillaria hepatica-infected rats.
dc.typeArticle


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