Thiocarbamates from Moringa oleifera Seeds Bioactive against Virulent and Multidrug-Resistant Vibrio Species

dc.creatorCosta, Renata Albuquerque
dc.creatorSousa, Oscarina Viana de
dc.creatorHofer, Ernesto
dc.creatorMafezoli, Jair
dc.creatorBarbosa, Francisco Geraldo
dc.creatorVieira, Regine Helena Silva dos Fernandes
dc.date2017-11-09T11:34:16Z
dc.date2017-11-09T11:34:16Z
dc.date2017
dc.date.accessioned2023-09-26T20:43:25Z
dc.date.available2023-09-26T20:43:25Z
dc.identifierCOSTA, Renata Albuquerque; et al. Thiocarbamates from Moringa oleifera Seeds Bioactive against Virulent and Multidrug-Resistant Vibrio Species. BioMed Research International, Volume 2017, Article ID7963747, 6p, 2017.
dc.identifier2314-6133
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/23087
dc.identifier10.1155/2017/7963747
dc.identifier2314-6141
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8862690
dc.descriptionProspect of antibacterial agents may provide an alternative therapy for diseases caused by multidrug-resistant bacteria. This study aimed to evaluate the in vitro bioactivity of Moringa oleifera seed extracts against 100 vibrios isolated from the marine shrimp Litopenaeus vannamei. Ethanol extracts at low (MOS-E) and hot (MOS-ES) temperature are shown to be bioactive against 92% and 90% of the strains, respectively. The most efficient Minimum Inhibitory Concentration (MIC) levels of MOS-E and MOS-ES against a high percentage of strains were 32 µg mL(-1). Bioguided screening of bioactive compounds showed that the ethyl acetate fraction from both extracts was the only one that showed antibacterial activity. Vibriocidal substances, niazirine and niazimicine, were isolated from the aforementioned fraction through chromatographic fractionation.
dc.formatapplication/pdf
dc.languageeng
dc.publisherHindawi Publishing Corporation
dc.rightsopen access
dc.subjectMoringa oleifera
dc.subjectResistência a múltiplos medicamentos
dc.subjectTiocarbamatos
dc.subjectMoringa oleifera
dc.subjectMultidrug-Resistant
dc.subjectThiocarbamates
dc.titleThiocarbamates from Moringa oleifera Seeds Bioactive against Virulent and Multidrug-Resistant Vibrio Species
dc.typeArticle


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