Article
Haemophilus influenzae meningitis 5 years after introduction of the Haemophilus influenzae type b conjugate vaccine in Brazil.
Registro en:
RIBEIRO, G. S. et al. Haemophilus influenzae meningitis 5 years after introduction of the Haemophilus influenzae type b conjugate vaccine in Brazil. Vaccine, v. 25, n. 22, p. 4420-4428, 2007.
0264-410X
10.1016/j.vaccine.2007.03.024
Autor
Ribeiro, Guilherme de Sousa
Lima, Josilene Borges T
Reis, Joice Neves
Gouveia, Edilane Lins
Cordeiro, Soraia Machado
Lôbo, Tatiana Silva
Pinheiro, Ricardo M
Ribeiro, Cássio Tâmara
Neves, Alan B
Salgado, Kátia M
Silva, Hagamenon R
Reis, Mitermayer Galvão dos
Ko, Albert Icksang
Resumen
The long-term impact of Haemophilus influenzae type b (Hib) conjugate vaccine, introduced throughout Latin America in the late 1990s,
has not been evaluated. Active surveillance for H. influenzae meningitis was performed from August 9, 1996 to August 8, 2004 in Metropolitan
Salvador, Brazil. Five years after the introduction of Hib conjugate vaccine, Hib meningitis incidence decreased from 2.39 to 0.06 cases per
100,000 population (98%) overall, and from 60.9 to 3.1 cases per 100,000 population (95%) in children <1 year of age. A transient serotype
replacement phenomenon was observed associated with a small increase of meningitis due to two H. influenzae type a clonal groups. These
findings indicate that Hib immunization campaign has led to the virtual elimination of Hib disease in this region.
© 2007 Elsevier Ltd. All rights reserved.
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