Histopathological and immunological characteristics of placentas infected with chikungunya virus

dc.creatorSalomão, Natália
dc.creatorRabelo, Kíssila
dc.creatorAvvad-Portari, Elyzabeth
dc.creatorOliveira, Carlos Basílio de
dc.creatorOliveira, Rodrigo Basílio de
dc.creatorFerreira, Fátima
dc.creatorFerreira, Luiz
dc.creatorSouza, Thiara Manuele de
dc.creatorNunes, Priscila
dc.creatorLima, Monique
dc.creatorSales, Anna Paula
dc.creatorFernandes, Regina
dc.creatorSouza, Luiz José de
dc.creatorDias, Laura
dc.creatorBrasil, Patrícia
dc.creatorSantos, Flavia dos
dc.creatorPaes, Marciano
dc.date2023-01-10T18:45:17Z
dc.date2023-01-10T18:45:17Z
dc.date2022
dc.date.accessioned2023-09-26T20:41:20Z
dc.date.available2023-09-26T20:41:20Z
dc.identifierSALOMÃO, Natália et al. Histopathological and immunological characteristics of placentas infected with chikungunya virus. Frontiers in Microbiology, v. 13, 1055536, p. 1-11, Nov. 2022.
dc.identifier1664-302X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/56432
dc.identifier10.3389/fmicb.2022.1055536
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8862042
dc.descriptionAlthough vertical transmission of CHIKV has been reported, little is known about the role of placenta in the transmission of this virus and the effects of infection on the maternal-fetal interface. In this work we investigated five placentas from pregnant women who became infected during the gestational period. Four formalin-fixed paraffin-embedded samples of placenta (cases 1–4) were positive for CHIKV by RT-PCR. One (case 5) had no positive test of placenta, but had positive RT-PCR for CHIKV in the serum of the mother and the baby, confirming vertical transmission. The placentas were analyzed regarding histopathological and immunological aspects. The main histopathological changes were: deciduitis, villous edema, deposits, villous necrosis, dystrophic calcification, thrombosis and stem vessel obliteration. In infected placentas we noted increase of cells (CD8+ and CD163+) and pro- (IFN-γ and TNF-α) and anti-inflammatory (TGF-β and IL-10) cytokines compared to control placentas. Moreover, CHIKV antigen was detected in decidual cell, trophoblastic cells, stroma villi, Hofbauer cells, and endothelial cells. In conclusion, CHIKV infection seems to disrupt placental homeostasis leading to histopathological alterations in addition to increase in cellularity and cytokines overproduction, evidencing an altered and harmful environment to the pregnant woman and fetus.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFrontiers Media
dc.rightsopen access
dc.subjectPlacenta
dc.subjectChikungunya
dc.subjectHistopatologia
dc.subjectImuno-histoquímica
dc.subjectCitocinas
dc.subjectPlacenta
dc.subjectChikungunya
dc.subjectHistopathology
dc.subjectImmunohistochemistry
dc.subjectCytokines
dc.titleHistopathological and immunological characteristics of placentas infected with chikungunya virus
dc.typeArticle


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