Article
Morphological and immuno-histochemical characterization of five phyllodes mammary gland tumors in dogs
Registro en:
ARAÚJO0, M. R. et al. Morphological and immuno-histochemical characterization of five phyllodes mammary gland tumors in dogs. Online Journal of Veterinary Research: OJVR, v. 18, n. 8, p. 688-695, 2014.
1328-925X
Autor
Araújo, Marina Rios de
Damasceno, Karine Araujo
Gamba, Conrado de Oliveira
Campos, Cecília Bonolo
Campos, Liliane Cunha
Reis, Diego Carlos dos
Souza, Cristina Maria de
Cassali, Geovanni Dantas
Resumen
Damasceno, Karine Araújo. Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) and Fundação de Amparo a Pesquisa de Minas Gerais (FAPEMIG),
Brazil. In
bitches, mammary tumors represent 52% of all neoplasms. The phyllodes tumor is a
rare fibro-epithelial neoplasm found in humans characterized by epithelial and
mesenchymal (stromal) cell proliferation creating elaborate leaf-like structures.
Morphological and immune-histochemical characteristics in 5 canine phyllodes tumors
are described. Four benign and one malignant phyllodes tumors were diagnosed.
Epithelial and stromal tumor cells were positive for cytokeratin AE1AE3 and vimentin,
respectively, and all were positive for estrogen and progesterone receptors. Benign
tumors were negative for p63 whereas the malignant tumor was positive for p63. Cell
proliferation index was <1% in benign tumors tissue but 69.5% in the malignant one.
All tumors were negative for c-KIT. The morphological and immune-phenotypical
aspects observed in this study suggest similarities between phyllodes tumors
diagnosed in women and in bitches. However, new studies are necessary to enhance
knowledge regarding the biological behavior of these neoplasms.