Article
The Yin Yang of Hormones that Control Glucose Homeostasis in Asthma
Registro en:
INSUELA, Daniela B. R. et al. The Yin Yang of Hormones that Control Glucose Homeostasis in Asthma. Allergy & Therapy, S11, 8p, 2013.
2155-6121
10.4172/2155-6121.S11-001
Autor
Insuela, Daniela B. R.
Silva, Patrícia M. R.
Martins, Marco A.
Carvalho, Vinicius F.
Resumen
Asthma is a chronic inflammatory disease whose prevalence has increased in the last 50 years. Several hormones
can determine the course of asthma pathogenesis. Furthermore, some endocrine disorders, including diabetes and
obesity, have been identified as important factors that influence the prevalence of asthma. These endocrine disorders
are characterized by presenting an imbalance in blood hormones levels that regulate glucose metabolism, including
hyperglycemic and hypoglycemic hormones. This review gives an update of the state-of-the-art concerning the
effect of hormones that control glucose homeostasis on asthma pathogenesis and development. Here, we proposed
that while hypoglycemic hormones, including insulin and leptin aggravate asthma, the hyperglycemic hormones, as
glucagon, glucocorticoids and epinephrine, have a protective effect on asthma.