Adenocarcinoma de cólon com diferenciação neuro-endócrina e escamosa. Relato de caso.
Arquivos de Gastroenterologia, v. 29, n. 2, p. 62-65, 1992.
Santos, G. C.
Coelho, Kunie Iabuki Rabello
Schmitt, F. C.
A tubular adenocarcinoma of the colon with solid area composed by small cells that was found by immunohistochemistry study using antibody to neuron-specific enolase (NSE) to possess neuroendocrine differentiation is related. In another areas of the tumor were visualized keratinizing squamous cells. The presence of neuro-endocrine and squamous cells features provide further evidence that neoplastic colonic cells have the capacity for multi-directional differentiation. The implications of this combination in relation to theories of tumor origin and differentiation and the prognostic significance of neuro-endocrine cells in malignant neoplasms of the gastrointestinal tract are discussed.