Morphological aspects of the myocarditis and myositis in Calomys callosus experimentally infected with Trypanosoma cruzi: fibrogenesis and spontaneous regression of fibrosis.

dc.creatorAndrade, Sonia Gumes
dc.creatorKloetzel, Judith K.
dc.creatorBorges, Monamaris Marques
dc.creatorFerrans, Victor J.
dc.date2012-10-19T21:14:46Z
dc.date2012-10-19T21:14:46Z
dc.date1994
dc.date.accessioned2023-09-26T20:35:58Z
dc.date.available2023-09-26T20:35:58Z
dc.identifierANDRADE, S.G. et al. Morphological aspects of the myocarditis and myositis in Calomys callosus experimentally infected with Trypanosoma cruzi: fibrogenesis and spontaneous regression of fibrosis. Memórias do Instituto Oswaldo Cruz, v. 89, n. 3, p. 379-93, jul.-sep. 1994.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/5700
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8860328
dc.descriptionCalomys callosus a wild rodent, is a natural host of Trypanosoma cruzi. Twelve C. callosus were infected with 10(5) trypomastigotes of the F strain (a myotropic strain) of T. cruzi. Parasitemia decreased on the 21st day becoming negative around the 40th day of infection. All animals survived but had positive parasitological tests, until the end of the experiment. The infected animals developed severe inflammation in the myocardium and skeletal muscle. This process was pronounced from the 26th to the 30th day and gradually subsided from the 50th day becoming absent or residual on the 64th day after infection. Collagen was identified by the picro Sirius red method. Fibrogenesis developed early, but regression of fibrosis occurred between the 50th and 64th day. Ultrastructural study disclosed a predominance of macrophages and fibroblasts in the inflammatory infiltrates, with small numbers of lymphocytes. Macrophages had active phagocytosis and showed points of contact with altered muscle cells. Different degrees of matrix expansion were present, with granular and fibrillar deposits and collagen bundles. These alterations subsided by the 64th days. Macrophages seem to be the main immune effector cell in the C. callosus model of infection with T. cruzi. The mechanisms involved in the rapid fibrogenesis and its regression deserve further investigation.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectTrypanosoma cruzi
dc.subjectCalomys callosus
dc.subjectMyocarditis
dc.subjectMyositis
dc.subjectFibrogenesis
dc.subjectFibroclasia
dc.subjectUltrastructure
dc.subjectCollagen
dc.subjectCardiomiopatia Chagásica/patologia
dc.subjectFibrose Endomiocárdica/patologia
dc.subjectMúsculo Esquelético/ultraestrutura
dc.subjectMiosite/patologia
dc.subjectAnimais
dc.subjectCricetinae
dc.subjectModelos Animais de Doenças
dc.subjectReservatórios de Doenças
dc.subjectMiocárdio/ultraestrutura
dc.subjectMiosite/parasitologia
dc.subjectRoedores/parasitologia
dc.titleMorphological aspects of the myocarditis and myositis in Calomys callosus experimentally infected with Trypanosoma cruzi: fibrogenesis and spontaneous regression of fibrosis.
dc.typeArticle


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