Bacterial nanocellulose containing diethylditiocarbamate bio-curatives: physicochemical characterization and drug delivery evaluation

dc.creatorBorba, Pedro B
dc.creatorMeneguin, Andréia Bagliotti
dc.creatorSilva, Jhonatan Miguel
dc.creatorBarud, Hernane da Silva
dc.creatorOliveira, Camila I. de
dc.date2022-03-07T14:47:52Z
dc.date2022-03-07T14:47:52Z
dc.date2022
dc.date.accessioned2023-09-26T20:34:07Z
dc.date.available2023-09-26T20:34:07Z
dc.identifierBORBA, Pedro B. et al. Bacterial nanocellulose containing diethylditiocarbamate bio-curatives: physicochemical characterization and drug delivery evaluation. Cellulose, v. 29, p. 1-9, 2022.
dc.identifier1572-882X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/51585
dc.identifier10.1007/s10570-021-04360-1
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8859699
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico. Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. Universidade de Araraquara.
dc.descriptionBacterial nanocellulose (BNC) is a natural biopolymer produced by different strains of acetic acid bacteria. Biocompatibility, lack of immunogenicity, mechanical strength and crystallinity make BNC a highly applicable product for drug delivery and wound dressing. Previously, we demonstrated that diethylditiocarbamate (DETC), a Superoxide Dismutase 1 inhibitor, incorporated into BNC bio-curatives was effective for treating Cutaneous leishmaniasis (CL) lesions, a parasitic disease caused by Leishmania. We herein investigated the interactions between DETC and BNC. For this purpose, DETC was incorporated into BNC and thermal analysis, x-ray diffraction and Scanning electron microscopy were performed. Furthermore, in vitro DETC release and stability tests as well as degradation studies were also performed. Our results show that DETC is well incorporated into BNC, however it is short lived as suggested by degradation experiments. Future use of BNC DETC-based bio-curatives for the treatment of CL shall require further development in order to increase stability of DETC in the bio-curative.
dc.formatapplication/pdf
dc.languageeng
dc.publisherSpringer
dc.rightsrestricted access
dc.subjectLeishmaniose
dc.subjectDitiocarb
dc.subjectLeishmaniasis
dc.subjectTopical delivery
dc.subjectDiethylditiocarbamate
dc.subjectDegradation
dc.subjectLeishmaniasis
dc.subjectDitiocarba
dc.subjectLeishmaniose
dc.subjectAcide diéthyl-dithiocarbamique
dc.titleBacterial nanocellulose containing diethylditiocarbamate bio-curatives: physicochemical characterization and drug delivery evaluation
dc.typeArticle


Este ítem pertenece a la siguiente institución