Article
High prevalence of parvovirus B19 infection in patients with chronic kidney disease under hemodialysis: a multicenter study
Registro en:
ALVES, Arthur Daniel Rocha et al. High prevalence of parvovirus B19 infection in patients with chronic kidney disease under hemodialysis: a multicenter study. International Journal of Infectious Diseases, [Hamilton], v. 100, p. 350-356, 2020.
1201-9712
10.1016/j.ijid.2020.09.010
Autor
Alves, Arthur Daniel Rocha
Langella, Barbara Barbosa
Barbosa, Jakeline Ribeiro
Lima, Danielle Malta
Colares, Jeová Keny Baima
Garcia, Rita de Cassia Nasser Cubel
Pinto, Marcelo Alves
Villar, Livia Melo
Amado, Luciane Almeida
Resumen
Instituto Oswaldo Cruz/ Fundação Oswaldo Cruz e Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. Objectives: Parvovirus B19 (B19V) infection is commonly acute and self-limited, but in chronic kidney
disease (CKD) patients under dialysis treatment, this infection could increase susceptibility to acute and
chronic anemia. The aim of this study was to evaluate the frequency and risk of B19V infection among
Brazilian CKD patients under dialysis.
Methods: A study was conducted among 221 CKD patients and a control group of 142 blood donors. B19V
infection was evaluated in serum samples by real-time PCR, and ELISA (anti-B19V IgM and IgG).
Results: B19V DNA was detected in 65% (145/221) of CKD patients, which was significantly higher (p <
0.001) than in the blood donors (6.3%). Simultaneous detection of B19V IgG and viremia was shown in
40.3% of CKD patients, which was indicative of persistent B19V infection. CKD patients showed an
increased risk of developing B19V infection (OR = 28.1, CI = 13.5–58.5, p = 0.001).
Conclusions: Despite an absence of clinical signs of B19V infection, these data highlight the importance of
B19V infection in this high-risk population, since a persistent B19V infection could become clinically
significant after renal transplant. Moreover, the persistent viremia should be considered as a potential
risk, mainly because of the contamination of dialysis equipment.