Thymic atrophy in acute experimental Chagas disease is associated with an imbalance of stress hormones

dc.creatorLepletier, Ailin
dc.creatorCarvalho, Vinícius de Frias
dc.creatorMorrot, Alexandre
dc.creatorSavino, Wilson
dc.date2017-04-18T17:27:45Z
dc.date2017-04-18T17:27:45Z
dc.date2012
dc.date.accessioned2023-09-26T20:31:55Z
dc.date.available2023-09-26T20:31:55Z
dc.identifierLEPLETIER, Ailin; et al. Thymic atrophy in acute experimental Chagas disease is associated with an imbalance of stress hormones. Ann. N.Y. Acad. Sci., v.1262, p.45-50, July 2012.
dc.identifier0077-8923
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/18506
dc.identifier10.1111/j.1749-6632.2012.06601.x
dc.identifier1749-6632
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8858943
dc.descriptionDisorders in the hypothalamic-pituitary-adrenal axis are associated with the pathogenesis of Trypanosoma cruzi infection. During the acute phase of this disease, increased levels of circulating glucocorticoids (GCs) correlate with thymic atrophy. Recently, we demonstrated that this phenomenon is paralleled by a decrease of prolactin (PRL) secretion, another stress hormone that seems to counteract many immunosuppressive effects of GCs. Both GCs and PRL are intrathymically produced and exhibit mutual antagonism through the activation of their respective receptors, GR, and PRLR. Considering that GCs induce apoptosis and inhibit double-positive (DP) thymocyte proliferation and that PRL administration prevents these effects, it seems plausible that a local imbalance of GR-PRLR crosstalk underlies the thymic involution occurring in acute T. cruzi infection. In this respect, preserving PRLR signaling seems to be crucial for protecting DP from GC-induced apoptosis.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherWiley
dc.rightsrestricted access
dc.subjectTrypanosoma cruzi
dc.subjectAtrofia do Timo
dc.subjectProlactina
dc.subjectRelação CD4-CD8
dc.subjectCélulas duplamente positivas
dc.subjectGlucocorticóides
dc.subjectDoença de Chagas
dc.subjectTrypanosoma cruzi
dc.subjectThymus Atrophy
dc.subjectprolactin
dc.subjectCD4+CD8+ double-positive cells
dc.subjectglucocorticoids
dc.subjectChagas disease
dc.titleThymic atrophy in acute experimental Chagas disease is associated with an imbalance of stress hormones
dc.typeArticle


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