Leprosy survey among rural communities and wild armadillos from Amazonas state, Northern Brazil

dc.creatorStefani, Mariane Martins Araújo
dc.creatorRosa, Patricia Sammarco
dc.creatorCosta, Mauricio Barcelos
dc.creatorSchetinni, Antônio Pedro Mendes
dc.creatorManhães, Igor
dc.creatorPontes, Maria Araci de Andrade
dc.creatorCosta, Patricia
dc.creatorFachin, Luciana Raquel Vincenzi
dc.creatorBaptista, Ida Maria Foschiani Dias
dc.creatorVirmond, Marcos da Cunha Lopes
dc.creatorPereira, Emília
dc.creatorPenna, Maria Lucia Fernandes
dc.creatorPenna, Gerson Oliveira
dc.date2020-05-08T15:39:46Z
dc.date2020-05-08T15:39:46Z
dc.date2019
dc.date.accessioned2023-09-26T20:31:22Z
dc.date.available2023-09-26T20:31:22Z
dc.identifierSTEFANI, Mariane Martins Araújo et al. Leprosy survey among rural communities and wild armadillos from Amazonas state, Northern Brazil. Plos One, [San Francisco], v. 14, n. 1, p. 1-13, Jan. 2018.
dc.identifier1932-6203
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/41169
dc.identifier10.1371/journal.pone.0209491
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8858745
dc.descriptionGerson Oliveira Penna - Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento.
dc.descriptionMS/DECIT/CNPq
dc.descriptionThere is evidence that in southern US, leprosy is a zoonosis infecting wild Dasypus novemcinctus armadillos but the extent of this finding is unknown. This ecological study investigated leprosy in rural communities and in wild armadillos from the Brazilian Amazon. The study area was the Mamiá Lake of Coari municipality, Amazonas State, Northern region, a hyper endemic leprosy area where residents live on subsistence farming, fishing and armadillo hunting and its meat intake are frequent. The leprosy survey was conducted in sixteen communities by a visiting team of specialists. Local partakers provided wild armadillos to investigate M. leprae infection. Volunteers had complete dermato-neurological examination by a dermatologist with expertise in leprosy diagnosis, suspect skin lesions were biopsied for histopathology (Hematoxylin-eosin/HE, Fite-Faraco/FF staining); slit skin smears were collected. Armadillos' tissue fragments (skins, spleens, livers, lymph nodes, adrenal glands, others) were prepared for histopathology (HE/FF) and for M. leprae repetitive element-RLEP-qPCR. Among 176 volunteers, six new indeterminate leprosy cases were identified (incidence = 3.4%). Suspect skin sections and slit skin smears were negative for bacilli. Twelve wild D. novemcinctus were investigated (48 specimens/96 slides) and histopathological features of M. leprae infection were not found, except for one skin presenting unspecific inflammatory infiltrate suggestive of indeterminate leprosy. Possible traumatic neuroma, granuloma with epithelioid and Langhans cells, foreign-body granuloma were also identified. Granulomatous/non-granulomatous dermatitides were periodic-acid-Schiff/PAS negative for fungus. M. leprae-RLEP-qPCR was negative in all armadillos' tissues; no bacillus was found in histopathology. Our survey in rural communities confirmed the high endemicity for leprosy while one armadillo was compatible with paucibacillary M. leprae infection. At least in the highly endemic rural area of Coari, in the Brazilian Amazon region where infectious sources from untreated multibacillary leprosy are abundant, M. leprae infected armadillos may not represent a major source of infection nor a significant public health concern.
dc.formatapplication/pdf
dc.languageeng
dc.publisherPublic Library of Science
dc.rightsopen access
dc.subjectDisease Reservoirs
dc.subjectLeprosy
dc.subjectLeprosy, Paucibacillary
dc.subjectMycobacterium leprae
dc.subjectRural Population
dc.subjectSkin Diseases
dc.subjectSurveys and Questionnaires
dc.subjectZoonoses
dc.subjectArmadillos
dc.subjectBrazil
dc.subjectSkin diseases
dc.subjectLeprosy
dc.subjectLeprosy, paucibacillary
dc.subjectMycobacterium leprae
dc.subjectArmadillos
dc.subjectZoonoses
dc.subjectDermatopatias
dc.subjectMycobacterium leprae
dc.subjectHanseníase
dc.subjectDoenças Transmissíveis
dc.subjectZoonoses
dc.subjectPopulação Rural
dc.subjectTatu
dc.titleLeprosy survey among rural communities and wild armadillos from Amazonas state, Northern Brazil
dc.typeArticle


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