Article
Domestic swine in a visceral leishmaniasis endemic area produce antibodies against multiple Leishmania infantum antigens but apparently resist to L. infantum infection.
Registro en:
SILVA, E. M. et al. Domestic swine in a visceral leishmaniasis endemic area produce antibodies against multiple Leishmania infantum antigens but apparently resist to L. infantum infection. Acta Tropica, v. 98, n. 2, p. 176-182, 2006.
0001-706X
Autor
Silva, Evandro Moraes
Antunes, Fabiana Rodrigues
Rodrigues, Márcio Silva
Julião, Fred da Silva
Lima, Artur Gomes Dias
Sousa, Valderez Lemos de
Alcantara, Adriano Costa de
Reis, Eliana Almeida Gomes
Nakatani, Maria
Badaró, Roberto José da Silva
Reis, Mitermayer Galvão dos
Pontes-de-Carvalho, Lain Carlos
Franke, Carlos Roberto
Resumen
In order to investigate whether pigs can be infected by Leishmania infantum, a serological and parasitological study was carried
out on swine in the Jequi´e municipality, Northeast of Brazil. Anti-Leishmania infantum antibodies were detected in 37 out of 92
swine (40.2%), by two different assays: an anti-L. infantum lysate and an anti-K39 recombinant protein ELISA. An experimental
study was also carried out to verify the susceptibility of domestic pigs to L. infantum infection. Three sows inoculated with 108
stationary-phase infective L. infantum promastigotes (26% metacyclic promastigotes) per kilogram of body weight produced anti-
Leishmania antibodies until the end of the experiment, 11 months later. No parasites, however, could be visualized through optical
microscopy of spleen, liver and bone marrowor by in vitro culture of these organs. Homogenates of these organs were also inoculated
in hamsters, without producing infection. No Leishmania DNA was detected by polymerase chain reaction (PCR) in sand flies fed
on these animals. The results indicate that domestic pigs bitten by L. infantum-infected vectors in the endemic area do not display
a full infection pattern, and the positive association in endemic areas between the presence of swine and infection in canines may
not be ascribable to the former acting as a parasite reservoir
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