Article
The effect of antihelminthic treatment on subjects with asthma from an endemic area of schistosomiasis: a randomized, double-blinded, and placebo-controlled trial
Registro en:
ALMEIDA, M. C. F. et al. The effect of antihelminthic treatment on subjects with asthma from an endemic area of schistosomiasis: a randomized, double-blinded, and placebo-controlled trial. Journal of Parasitology Research, art. ID 296856, 11 pages, 2012.
2090-0023
10.1155/2012/296856
Autor
Almeida, Maria Cecília F
Lima, Givaneide dos Santos
Cardoso, Luciana Santos
Souza, Robson da Paixão de
Campos, Régis de Albuquerque
Cruz Filho, Alvaro Augusto Souza da
Figueiredo, Joanemile Pacheco de
Oliveira, Ricardo Riccio
Carvalho Filho, Edgar Marcelino
Araujo, Maria Ilma Andrade Santos
Resumen
Carvalho Filho, Edgar Marcelino de; Oliveira, Ricardo Riccio. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. Brazilian National Research Council (CNPq). MIA, AAC and EMC are investigators supported by CNPq. This is a prospective, double-blinded, and placebo-controlled trial evaluating the influence of antihelminthic treatments on asthma severity in individuals living in an endemic area of schistosomiasis. Patients from group 1 received placebo of Albendazole or of Praziquantel and from group 2 received Albendazole and Praziquantel. Asthma severity was assessed by clinical scores and by pulmonary function test. There was no significant difference in the asthma scores from D0 to D1-D7 after Albendazole or Praziquantel and from D0 to D30-90 after Albendazole or Praziquantel in both, group 1 and 2. It was observed, however, a clinical worsening of the overall studied population after 6 months and 12 months of antihelminthic treatments. Additionally, we observed increased frequency of forced expiratory volume in 1 second (FEV1) <80% on 12 and 18 months after treatment. The worsening of asthma severity after repeated antihelminthic treatments is consistent with the hypothesis of the protective role conferred by helminths in atopic diseases.