Article
Association of hepatosplenic schistosomiasis with HLA-DQB1*0201
Registro en:
SECOR, E. W. et al. Association of hepatosplenic schistosomiasis with HLA-DQB1*0201. Journal of Infectious Disease, v. 174, n, 5, p. 1131-1135, 1996.
0022-1899
Autor
Secor, William E
Del Corral, Helena
Reis, Mitermayer Galvão dos
Ramos, Eduardo Antônio Gonçalves
Zimon, Alison E
Matos, E. Peixoto
Reis, Eliana Almeida Gomes
Carmo, Theomira Mauadie de Azevedo
Hirayama, Kenji
David, Roberta A
David, John R
Harn Junior, Donald A
Resumen
Major histocompatibility class II alleles of 351 persons living in an area endemic for Schistosoma
mansoni in northeastern Brazil were characterized at three loci (DRBl, DQAl, and DQBl). Contingency
analyses were used to compare allele frequencies witfihigh egg excretion, proliferative response
to schistosome soluble egg antigens (SEA), and occurrence of severe, biopsy-confirmed hepatosplenic
disease. There were no associations of HLA-DR or DQ with egg excretion. Patients positive for
DRBl*Ol, DQAl*0101, or DQBl*0501 were less likely to respond to SEA than was the overall
study population. However, using stringent Bonferroni correction (multiplying P values by the
number of alleles tested; P X 35), none of these associations with SEA responsiveness remained
significant. Hepatosplenic disease was less likely in patients positive for DRBI*11 and was more
likely in patients positive for DRBl*07 or DQBl*0201. However, only the DQBl*0201 association
remained significant (odds ratio = 3.72; P < .005) following Bonferroni correction.