Article
Dengue infection in pregnancy and its impact on the placenta
Registro en:
RIBEIRO, Christiane Fernandes et al. Dengue infection in pregnancy and its impact on the placenta. International Journal of Infectious Diseases, v. 55, p. 109-112, 2017.
1201-9712
10.1016/j.ijid.2017.01.002
1878-3511
Autor
Ribeiro, Christiane Fernandes
Lopes, Vânia Glória Silami
Brasil, Patrícia
Pires, Andrea Rodrigues Cordovil
Rohloff, Roger
Nogueira, Rita Maria Ribeiro
Resumen
A histopathological and immunohistochemical study was conducted in placental tissues and retained products of conception from 24 patients with confirmed dengue infection during pregnancy. The immunohistochemical assay was positive for dengue virus in 19 placental and three ovular remnants analyzed. The light microscopic findings were signs of hypoxia, choriodeciduitis, deciduitis and intervillositis and the viral antigens were found in cytoplasmic of the trophoblast, villous stroma and decidua. Our results suggest that immunohistochemistry could be used as a laboratory confirmation method for dengue in pregnant women, especially in endemic areas when embedded material is the only material available. 2030-01-01