Article
Merozoite surface protein 2 allelic variation influences the specific antibody response during acute malaria in individuals from a Brazilian endemic area
Registro en:
SALLENAVE-SALES, Selma et al. Merozoite surface protein 2 allelic variation influences the specific antibody response during acute malaria in individuals from a Brazilian endemic area. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, n. 3, p. 421-424, June 2007.
0074-0206
10.1590/S0074-02762007005000048
1678-8060
Autor
Sallenave-Sales, Selma
Faria, Clarissa Perez
Zalis, Mariano Gustavo
Ribeiro, Cláudio Tadeu Daniel
Cruz, Maria de Fátima Ferreira da
Resumen
The antibody response to Plasmodium falciparum parasites of naturally infected population is critical to
elucidate the role of polymorphic alleles in malaria. Thus, we evaluated the impact of antigenic diversity of
repetitive and family dimorphic domains of the merozoite surface protein 2 (MSP-2) on immune response of 96
individuals living in Peixoto de Azevedo (MT-Brazil), by ELISA using recombinant MSP-2 proteins. The majority
of these individuals were carrying FC27-type infections. IgG antibody responses were predominantly directed
to FC27 parasites and were correlated to the extension of polymorphism presented by each MSP-2
region. This finding demonstrated the impact of the genetic polymorphism on antibody response and therefore,
its importance on malaria vaccine efficacy.