Heart disease and arboviruses: a systematic review and meta-analysis

dc.creatorNicacio, Jandir Mendonça
dc.creatorGomes, Orlando Vieira
dc.creatorCarmo, Rodrigo Feliciano do
dc.creatorNunes, Sávio Luiz Pereira
dc.creatorRocha, José Roberto Coelho Ferreira
dc.creatorSouza, Carlos Dornels Freire de
dc.creatorFranca, Rafael Freitas de Oliveira
dc.creatorKhouri, Ricardo
dc.creatorBarral Netto, Manoel
dc.creatorArmstrong, Anderson da Costa
dc.date2023-01-10T13:05:28Z
dc.date2023-01-10T13:05:28Z
dc.date2022
dc.date.accessioned2023-09-26T20:24:38Z
dc.date.available2023-09-26T20:24:38Z
dc.identifierNICACIO, Jandir Mendonça et al. Heart disease and arboviruses: a systematic review and meta-analysis. Viruses, v. 14, p. 1-18, 2022.
dc.identifier1999-4915
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/56418
dc.identifier10.3390/ v14091988
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8856280
dc.descriptionDengue fever, chikungunya, and zika are highly prevalent arboviruses transmitted by hematophagous arthropods, with a widely neglected impact in developing countries. These diseases cause acute illness in diverse populations, as well as potential cardiovascular complications. A systematic review was carried out to investigate the burden of cardiac involvement related to these arboviruses. Multiple databases were searched for articles that investigated the association of cardiovascular diseases with arboviruses, published up to March 2022. Relevant articles were selected and rated by two independent reviewers. Proportion meta-analysis was applied to assess the frequency-weighted mean of the cardiovascular findings. A total of 42 articles were selected (n = 76,678 individuals), with 17 manuscripts on dengue and 6 manuscripts on chikungunya undergoing meta-analysis. The global pooled incidence of cardiac events in dengue fever using a meta-analysis was 27.21% (95% CI 20.21–34.83; I2 = 94%). The higher incidence of dengue-related myocarditis was found in the population younger than 20 years old (33.85%; 95% CI 0.00–89.20; I2 = 99%). Considering the studies on chikungunya (n = 372), the global pooled incidence of cardiac involvement using a meta-analysis was 32.81% (95% CI 09.58–61.49, I2 = 96%). Two Zika studies were included that examined cases of infection by vertical transmission in Brazil, finding everything from structural changes to changes in heart rate variability that increase the risk of sudden death. In conclusion, cardiac involvement in arboviruses is not uncommon, especially in dengue fever.
dc.formatapplication/pdf
dc.languageeng
dc.publisherMDPI
dc.rightsopen access
dc.subjectArbovírus
dc.subjectEnvolvimento cardíaco
dc.subjectDengue
dc.subjectChikungunya
dc.subjectZika
dc.subjectArboviruses
dc.subjectCardiac involvement
dc.subjectDengue
dc.subjectChikungunya
dc.subjectZika
dc.subjectArbovírus
dc.subjectDoenças Cardiovasculares
dc.subjectDengue
dc.subjectChikungunya
dc.subjectZika
dc.titleHeart disease and arboviruses: a systematic review and meta-analysis
dc.typeArticle


Este ítem pertenece a la siguiente institución