Article
Monoclonal antibodies for the identification of New World Leishmania species
Registro en:
GRIMALDI JR., Gabriel; MCMAHON-PRATT, Diane. Monoclonal antibodies for the identification of New World Leishmania species. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 91, n. 1, p. 37-42, Jan./Feb. 1996.
0074-0276
10.1590/S0074-02761996000100006
1678-8060
Autor
Grimaldi Jr., Gabriel
McMahon-Pratt, Diane
Resumen
Monoclonal antibodies specific for selected species complexes of Leishmania have been employed for the characterization of several representative strains of Leishmania isolated from different hosts and localities in the Americas. In the past 15 years, data have been accumulated concerning (i) the specificities of a number of these monoclonal antibodies and (ii) the antigenic variation (level of the expressed antigenic determinants) occurring among New World Leishmania species or strain variants as recognized by the monoclonal antibodies. This report is an attempt to summarize in brief the data accumulated to date on these points and to indicate the directions for future applications of these specific monoclonal antibodies for identification of leishmanial isolates.