Article
High interleukin 17 expression is correlated with better cardiac function in human Chagas disease
Registro en:
MAGALHÃES, Luisa Mourao Dias et al. High interleukin 17 expression is correlated with better cardiac function in human Chagas disease. J Infect Dis., v. 207, n. 4, p. 661-665, 2013
0022-1899
10.1093/infdis/jis724
Autor
Magalhães, Luisa Mourao Dias
Villani, Fernanda Nobre Amaral
Nunes, Maria do Carmo Pereira
Gollob, Kenneth John
Rocha, Manoel Otavio da Costa
Dutra, Walderez Ornelas
Resumen
This study was designed to investigate whether the expression of interleukin 17 (IL-17) is associated with the indeterminate or cardiac clinical forms of Chagas disease and whether IL-17 expression can be correlated with patients’ cardiac function. Our results demonstrated that cardiac Chagas patients have a lower intensity of expression of IL-17 by total lymphocytes and lower frequency of circulating T helper 17 cells. Correlative analysis showed that high IL-17 expression was associated with better cardiac function, as determined by left ventricular ejection fraction and left ventricular diastolic diameter values. Therefore, IL-17 expression can be a protective factor to prevent myocardial damage in human Chagas disease. 2020-01-01