Article
Natural Products as a Source for New Anti-Inflammatory and Analgesic Compounds through the Inhibition of Purinergic P2X Receptors
Registro en:
BEZERRA, Rômulo José Soares; et al.Natural Products as a Source for New Anti-Inflammatory and Analgesic Compounds through the Inhibition of Purinergic P2X Receptors. Pharmaceuticals, v.6, n.5, p.650-658, 2013.
1424-8247
10.3390/ph6050650
Autor
Bezerra, Rômulo José Soares
Calheiros, Andrea Surrage
Ferreira, Natiele Carla da Silva
Frutuoso, Valber da Silva
Alves, Luiz Anastácio
Resumen
Natural products have reemerged in traditional medicine as a potential source of
new molecules or phytomedicines to help with health disorders. It has been established that
members of the P2X subfamily, ATP-gated ion channels, are crucial to the inflammatory
process and pain signalization. As such, several preclinical studies have demonstrated that
P2X2R, P2X3R, P2X4R and P2X7R are promising pharmacological targets to control
inflammatory and pain disorders. Several studies have indicated that natural products could
be a good source of the new specific molecules needed for the treatment of diseases linked
to inflammation and pain disorders through the regulation of these receptors. Herein, we
discuss and give an overview of the applicability of natural products as a source to obtain
P2X receptors (P2XR) selective antagonists for use in clinical treatment, which require
further investigation.