Article
Studies on anti-componenet 5 antibodies in animals infected with Trypanosoma cruzi
Registro en:
SANTORO, F. et al. Studies on anti-componenet 5 antibodies in animals infected with Trypanosoma cruzi. Revista da Sociedade Brasileira de Medicina Tropical, v. 20, n. 2, p. 91-94, 1987.
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Autor
Santoro, Ferrucio
Sadigursky, Moysés
Sherlock, Ítalo Rodrigues de Araújo
Afchain, Daniel
Capron, A.
Resumen
A competitive antibody enzyme immunoassay, using a monoclonal antibody against
the species-specific Trypanosoma cruzi antigen 5, was used to investigate the presence o f
anti-component 5 antibodies in sera of opossums, dogs, rabbits and rats infected with this
parasite. The sera from 51 Venezuelan patients with Chagas’disease were also tested. About
90% of the infected subjects showed significant levels o f anti-component 5 antibodies.
Nevertheless, these antibodies were not detected in the sera o f dogs, rats and opossums
infected with T. cruzi. Some sera from infected rabbits presented significant results but
close to the limit o f positivity o f the test. Thesefindings suggest that the immune response
in animals naturally or experimentally infected with T. cruzi is different from that
observed in human Chagas’disease.