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Biological and molecular characterization of clonal populations of Trypanosoma cruzi strains: 21SF – Biodeme Type II and Colombian strain – Biodeme Type III, isolated from infected mice, treated with Benznidazole and not cured
Registro en:
MORAIS, I. R. B. et al. Biological and molecular characterization of clonal populations of Trypanosoma cruzi strains: 21SF – Biodeme Type II and Colombian strain – Biodeme Type III, isolated from infected mice, treated with Benznidazole and not cured. In: CONGRESSO INTERNACIONAL DE MEDICINA TROPICAL E MALÁRIA, 18 e CONGRESSO DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 48., 2012, Rio de Janeiro. Resumos... Rio de Janeiro: Sociedade Brasileira de Medicina Tropical, 2012.
Autor
Morais, Isa Rita Brito de
Guerreiro, Marcos Lázaro da Silva
Patriota, G. S. Q
Santos, Viviane Corrêa
Macedo, Andrea Mara
Andrade, Sonia Gumes
Resumen
Introduction: Different strains and clones of Trypanosoma cruzi present different degrees of
susceptibility to treatment with chemotherapic drugs. Several studies have been developed to evaluate
the response to different drugs concerning the strains prototypes of Biodemes Types I, II and III
according to the biological characterization. Results have shown that the strains prototypes of the
Biodeme Type I (Y and Peruvian strains) disclosed a high susceptibility to treatment with Benznidazole
and Nifurtimox; strains of the Biodeme Type II (prototype: the 21SF strain) showed a medium
susceptibility; the strains of the Biodeme Type III (Colombian strain) were highly resistant