Article
Design, synthesis and biological evaluation of 3-[4-(7-chloro-quinolin-4-yl)-piperazin-1-yl]-propionic acid hydrazones as antiprotozoal agents.
Registro en:
INAM, A. et al. Design, synthesis and biological evaluation of 3-[4-(7-chloro-quinolin-4-yl)-piperazin-1-yl]-propionic acid hydrazones as antiprotozoal agents. European Journal of Medicinal Chemistry, v. 75, p. 67-76, 2014.
1768-3254
10.1016/j.ejmech.2014.01.023
Autor
Inam, Afreen
Siddiqui, Shadab Miyan
Macedo, Taís Soares
Moreira, Diogo Rodrigo Magalhães
Leite, Ana Cristina Lima
Soares, Milena Botelho Pereira
Azam, Amir
Resumen
N-Acylhydrazones derived from 7-chloro-4-piperazin-1-yl-quinoline were synthesized and biologically
evaluated for blood-stage of Plasmodium falciparum and Entamoeba histolytica trophozoites. N-Acylhydrazone
F12 was found to inhibit the P. falciparum growth as well as its life cycle with good selectivity,
which was achieved by inhibiting hematin formation. Compound F24 showed better IC50 value than the
amoebicidal drug metronidazole