Evaluation of spleen cell population and effect of splenectomy on granuloma modulation in BALB/c mice infected with Schistosoma mansoni.

dc.creatorArruda, Sérgio Marcos
dc.creatorSantoro, Ferrucio
dc.creatorSadigursky, Mauricio
dc.date2012-10-22T18:05:41Z
dc.date2012-10-22T18:05:41Z
dc.date1993
dc.date.accessioned2023-09-26T20:20:11Z
dc.date.available2023-09-26T20:20:11Z
dc.identifierARRUDA, S.M.; SANTORO, F.; SADIGURSKY, M. Evaluation of spleen cell population and effect of splenectomy on granuloma modulation in BALB/c mice infected with Schistosoma mansoni. Memórias do Instituto Oswaldo Cruz, v. 88, n. 1, p. 97-102, jan.-mar. 1993.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/5706
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8854533
dc.descriptionA kinetic study of the cells present in the spleen of BALB/c mice infected with Schistosoma mansoni was carried out. The lymphocytes were evaluated phenotypically with monoclonal antibodies and the effect of splenectomy on the modulation of periovular granuloma was also investigated. The infected mice had proportional increases in the numbers of neutrophils, plasma cells, macrophages and eosinophils in the spleen. The largest number of neutrophil, plasma cells and macrophage were found between the 8th and the 12th week of infection, while the amount of eosinophils were higher later on, around the 20th week. The lymphocytes phenotypically characterized as Thy 1.2, Lyt 1.2 (CD4) increased mildly in proportional numbers. However, the percentage of lymphocytes with the Lyt 2.2 (CD8) phenotype, which is characteristic of suppressor and cytotoxic T cells, increased significantly with the progress of the disease. The numbers of B lymphocytes, which comprise 50% of the mononuclear cells present in the spleen, increased significantly till the 16th week when they began to decrease. The mean diameters of periovular granulomas were comparatively similar in both experimental groups (splenectomized and non-splenectomized mice). However, the evolutive types of granuloma (exudative, intermediate and fibrous) in splenectomized mice were proportionally different from those of non splenectomized mice in the 16th and 24th week of infection. It is inferred that lymphnodes or other secondary lymphoid organs, in the absence of the spleen, assume a modulating action on periovular granulomas, although the evolution of the granulomas is somehow delayed in splenectomized mice.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectSchistosoma mansoni
dc.subjectMurine schistosomiasis
dc.subjectGranuloma modulation
dc.subjectSplenectomy
dc.subjectLymphocytes
dc.subjectEsquistossomose mansoni/patologia
dc.subjectBaço/patologia
dc.subjectEsplenectomia
dc.subjectAnimais
dc.subjectGranuloma/patologia
dc.subjectHepatopatias/patologia
dc.subjectCamundongos
dc.subjectCamundongos Endogâmicos BALB C
dc.subjectTamanho do Órgão
dc.titleEvaluation of spleen cell population and effect of splenectomy on granuloma modulation in BALB/c mice infected with Schistosoma mansoni.
dc.typeArticle


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