Joint production of IL-22 participates in the initial phase of antigen-induced arthritis through IL-1β production

Pinto, Larissa G.; Talbot, Jhimmy; Peres, Raphael S.; Franca, Rafael F.; Ferreira, Sérgio H.; Ryffel, Bernhard; Aves-Filho, José Carlos F.; Figueiredo, Florêncio; Cunha, Thiago M.; Cunha, Fernando Q.

Article

Registro en:

PINTO, L. G. et al. Joint production of IL-22 participates in the initial phase of antigen-induced arthritis through IL-1β production. Arthritis Research & Therapy, v. 17, p. 235, 2 set. 2015.

1478-6362

https://www.arca.fiocruz.br/handle/icict/21078

10.1186/s13075-015-0759-2

https://repositorioslatinoamericanos.uchile.cl/handle/2250/8853652

Autor

Pinto, Larissa G.

Talbot, Jhimmy

Peres, Raphael S.

Franca, Rafael F.

Ferreira, Sérgio H.

Ryffel, Bernhard

Aves-Filho, José Carlos F.

Figueiredo, Florêncio

Cunha, Thiago M.

Cunha, Fernando Q.

Institución

Instituto de Comunicação e Informação Científica e Tecnológica em Saúde (Brasil)

Resumen

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by neutrophil articular infiltration, joint pain and the progressive destruction of cartilage and bone. IL-22 is a key effector molecule that plays a critical role in autoimmune diseases. However, the function of IL-22 in the pathogenesis of RA remains controversial. In this study, we investigated the role of IL-22 in the early phase of antigen-induced arthritis (AIA) in mice.